Exploring the Molecular Mechanism of Polygonum Multiflorum in Treating Androgenic Alopecia Using Bioinformatics and Molecular Docking

    July 2025 in “ Medicine ”
    Xiaoling Zhong, 聡史 壷井
    Studysummary This study explored the molecular mechanisms by which Polygonum multiflorum may treat androgenic alopecia, suggesting it influences cell apoptosis and inflammation through specific pathways, with potential application value pending further testing.
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    Research cited in this study 16

    1. Efficacy Comparison of Monotherapies and Combination Therapies for Androgenetic Alopecia: A Bayesian Network Meta-Analysis Dermatologic Therapy · 2021
    2. Androgenetic Alopecia: Update on Etiology Dermatological reviews · 2021
    3. Hormonal Regulation in Male Androgenetic Alopecia: Sex Hormones and Beyond - Evidence from Recent Genetic Studies Experimental Dermatology · 2020
    4. Topical Finasteride for the Treatment of Male Androgenetic Alopecia and Female Pattern Hair Loss: A Review of the Current Literature Journal of Dermatological Treatment · 2020
    5. The Effectiveness of Combination Therapies for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Dermatologic Therapy · 2020
    6. Early-Onset Androgenetic Alopecia in China: A Descriptive Study of a Large Outpatient Cohort Journal of International Medical Research · 2020
    7. Herbal Preparations for the Treatment of Hair Loss Archives of Dermatological Research · 2019
    8. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    9. Efficacy of Off-Label Topical Treatments for the Management of Androgenetic Alopecia: A Review Clinical Drug Investigation · 2019
    10. Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors Assay and Drug Development Technologies · 2018
    11. JAK-Inhibitors in Dermatology: Current Evidence and Future Applications Journal of dermatological treatment · 2018
    12. Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation Nutrients · 2018
    13. Female Pattern Hair Loss: A Clinical, Pathophysiologic, and Therapeutic Review International Journal of Women's Dermatology · 2018
    14. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    15. Androgenetic Alopecia: Drug Safety and Therapeutic Strategies Expert Opinion on Drug Safety · 2018
    16. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017

    Related research 1

    1. Topical Application of Polygonum Multiflorum Extract Induces Hair Growth of Resting Hair Follicles Through Upregulating Shh and β-Catenin Expression in C57BL/6 Mice Journal of Ethnopharmacology · 2011