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Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter on Human Dermal Fibroblasts

research Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter (PM10) on Human Dermal Fibroblasts

68 citations , September 2018 in “International Journal of Molecular Sciences”

In this study, researchers found that exposure to PM10 significantly increased inflammation and impaired collagen synthesis in human dermal fibroblasts, suggesting PM10 contributes to skin aging through these mechanisms.

The Silver Locus Product (Silv/gp100/Pmel17) as a New Tool for the Analysis of Melanosome Transfer in Human Melanocyte–Keratinocyte Co-Culture

research The silver locus product (Silv/gp100/Pmel17) as a new tool for the analysis of melanosome transfer in human melanocyte–keratinocyte co‐culture

68 citations , March 2008 in “Experimental dermatology”

This study introduced a novel in vitro assay for tracking melanosome transfer between melanocytes and keratinocytes, facilitating the quantification of melanin transfer and supporting the role of filopodia as a conduit.

research Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice

58 citations , February 2016 in “Scientific reports”

This study found that dual inhibition of BACE1 and BACE2 in mice affects melanosome maturation and causes dose-dependent hair depigmentation without altering retinal morphology.

research Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis

29 citations , January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, silencing P-cadherin in human scalp hair follicles reduced melanogenesis and associated protein expression, suggesting P-cadherin is crucial for normal hair pigmentation via GSK3β-mediated Wnt signaling.

research Effect of a novel steroid (PM-9) on the inhibition of 5α-reductase present in Penicillium crustosum broths

22 citations , March 2003 in “Steroids”

This study found that both finasteride and a new steroidal compound, PM-9, competitively inhibit the 5α-reductase enzyme in Penicillium crustosum broth.

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Community Join

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community Oral Min - AM/PM Split Dose or PM Full Dose?

in Minoxidil 1 upvotes 8 months ago

The conversation discusses whether to take oral minoxidil in a split dose or a single dose at night. Users suggest that taking a single 10mg dose at night is simpler, while splitting may help minimize side effects.

community Oral minoxidil and horrible PMS correlation or causation? Tips?

in Female 1 upvotes 2 years ago

A user reported significant hair improvement using oral minoxidil, Rogaine 5%, and spironolactone but experienced worsening PMS. They seek advice on managing the PMS symptoms.

community Dutasteride is amazing even for women with FAGA!

in Female 151 upvotes 1 year ago

Dutasteride significantly improved hair health and reduced shedding for a woman with PCOS and hyperandrogenism, without causing depression or anxiety, unlike finasteride. Dutasteride also helped with PMDD symptoms and had no side effects, though it changed hair texture.

community 10-Months of 1.25mg Fin EOD No Minoxidil | 23M

94 upvotes 11 months ago

A 23-year-old male used 1.25mg finasteride every other day for 10 months without minoxidil, noticing results at the 4-month mark and experiencing a minor shed at the 8-month mark. He also added Nizoral to his routine and reported no side effects, maintaining consistent use at 7:00 PM.

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Clinics

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Experts

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63
Dermatologist
Shailaja Pm, MBBS
Bengaluru, Karnataka, India

Learn

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learn Scalp Micropigmentation

Do I need a consultation before starting scalp micropigmentation? A consultation is highly recommended before starting scalp micropigmentation for best results.

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Shailaja Pm, MBBS