Polyglandular Autoimmune Syndrome Type 4 with GAD Antibody and Dystonia
February 2012
in “
Clinical Neurology and Neurosurgery
”
TLDR Dystonia may be part of PAS-4 and linked to immune issues.
This case report described a 20-year-old man with polyglandular autoimmune syndrome type 4 (PAS-4) who presented with dystonia, type 1 diabetes mellitus (DM), alopecia, vitiligo, and myasthenia gravis (MG). Despite immune modulation therapy and thymectomy, his dystonia persisted, suggesting a different underlying mechanism. The study highlighted that dystonia could be part of PAS-4 and recommended checking for anti-GAD antibodies in patients with PAS and neurological disorders. The findings suggested that the dystonia might be immune-mediated and related to disruptions in the cortico-basal ganglia circuitry.
