Cell Membrane-Camouflaged Nanoparticles Mediated Nucleic Acids Delivery

    December 2023 in “ International Journal of Nanomedicine ”
    Yinshan Lin, Xiaoling Guan, Jianfen Su, Sheng Chen, Xihua Fu, Xiaowei Xu, Xiaohua Deng, Jishuo Chang, Aiping Qin, Ao Shen, Lingmin Zhang
    TLDR Cell membrane-coated nanoparticles could improve gene therapy by enhancing delivery and targeting of nucleic acids.
    The document explores the use of cell membrane-camouflaged nanoparticles (CMCNPs) for delivering nucleic acids in gene therapy, addressing challenges like degradation and targeting. CMCNPs, coated with membranes from cells such as erythrocytes, platelets, and macrophages, enhance biocompatibility, reduce immune recognition, and improve targeting and cellular uptake. These nanoparticles show promise in cancer therapy and inflammatory disease treatment by leveraging the unique properties of different cell membranes. Despite challenges like variability in membrane sources and potential immunogenicity, CMCNPs are expected to advance nucleic acid delivery systems, potentially revolutionizing gene therapy.
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