Film-Trigger Applicator for Improved Skin Penetration of Microneedles Using Punching Force of Carboxymethyl Cellulose Film

September 2022 in “ Biomaterials Research ”

You-Seong Kim, Hye Su Min, Jiwoo Shin, Jeehye Nam, Geonwoo Kang, Jeeho Sim, Huisuk Yang, Hyungil Jung

microneedle dissolving microneedles carboxymethyl cellulose CMC skin penetration drug delivery plasma insulin

TLDR The film-trigger applicator improves microneedle skin delivery and drug efficiency using simple finger force.

The study introduced a film-trigger applicator (FTA) system designed to improve the delivery of dissolving microneedles (DMNs) into the skin, using the fracture energy of carboxymethyl cellulose (CMC) film. This system demonstrated enhanced drug delivery efficiency compared to traditional DMN patches, as evidenced by improved skin penetration and higher plasma insulin levels in C57BL/6 mice. The FTA system, which operates with simple finger force and does not require complex external devices, showed promise as a next-generation microneedle applicator, potentially overcoming the limitations of conventional DMN patch systems.

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Film-Trigger Applicator for Improved Skin Penetration of Microneedles Using Punching Force of Carboxymethyl Cellulose Film

Research cited in this study

research Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia

research Transcutaneous Implantation of Valproic Acid-Encapsulated Dissolving Microneedles Induces Hair Regrowth

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