Effects of Transient Receptor Potential (TRP) Channel Agonists and Antagonists on Slowly Adapting Type II Mechanoreceptors in the Rat Sinus Hair Follicle

December 2009 in “ Journal of the Peripheral Nervous System ”

Peter Cahusac

transient receptor potential channels TRP channels capsazepine ruthenium red icilin cinnamaldehyde camphor capsaicin allyl isothiocyanate TRPA1 TRPV1 TRPA1 channels TRPV1 channels

TLDR TRPA1 and TRPV1 channels don't affect mechanotransduction in rat sinus hair follicles.

The study investigated the role of transient receptor potential (TRP) channels in rat sinus hair follicles by testing various TRP agonists and antagonists on slowly adapting type II mechanoreceptors. Capsazepine, a TRP antagonist, was found to depress both spontaneous and mechanically evoked activity, with an IC 50 of 82 µM, and selectively affected mechanically evoked firing in some units. Ruthenium red showed inconsistent effects, while icilin increased spontaneous firing. Cinnamaldehyde and camphor depressed all types of activity, with camphor having a stronger effect on spontaneous activity. Capsaicin and allyl isothiocyanate showed no clear effects. The findings suggested that TRPA1 and TRPV1 channels did not play a role in the mechanotransduction processes of these mechanoreceptors.

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