Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential

    June 2021 in “ Frontiers in Pharmacology ”
    Xinyu Cui, Wuyue Chen, Haoyan Zhou, Yuan Gong, Bowen Zhu, Xiang Lv, Hongbo Guo, Jin‐Ao Duan, Jing Zhou, Edyta Marcon, Hongyue Ma
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    Studysummary This review examines the mechanisms of lung fluid imbalance in COVID-19-related pulmonary edema and suggests potential drug targets to improve management and reduce mortality. Our plain-language summary of this paper — not a Tressless recommendation.
    The document discussed how COVID-19 mortality was largely due to pulmonary edema, caused by abnormal alveolar fluid metabolism in the lungs as a result of SARS-CoV-2 infection. It explored various mechanisms leading to pulmonary edema in severe COVID-19 cases and emphasized the importance of understanding these mechanisms for effective management. The authors highlighted that current therapeutic strategies had largely overlooked the role of abnormal lung humoral metabolism. They suggested that targeting this aspect could reduce COVID-19 mortality and alleviate the burden on healthcare systems by potentially decreasing the need for ventilator-assisted respiration.
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