December 2023 in “Journal of molecular structure” This study found that hair membrane fluidity is low in the cuticle but high in the cortex and medulla, with treatments like ionic surfactants and oleic acid increasing fluidity in hydrated hair; however, dehydration significantly reduces fluidity throughout the hair.
March 2025 in “Scientific Reports” This study evaluated a menthol-based microemulsion for transdermal delivery of finasteride and silodosin, finding that it enhanced skin permeation and flux compared to aqueous solutions, suggesting a promising method for managing benign prostatic hyperplasia.
January 2026 in “Derecho y cambio social.” This narrative review found that fragrances and isothiazolinone preservatives in deodorants are key contributors to skin sensitization, while magnesium hydroxide shows promise as a less irritating alternative for managing body odor without blocking sweat ducts.
July 2025 in “Colloids and Surfaces B Biointerfaces” This study found that the new delivery system HL@Mi enhanced the skin penetration, local bioavailability, and safety of minoxidil, supporting improved hair growth in an androgenetic alopecia animal model.
January 2011 in “Journal of Society of Cosmetic Chemists of Japan” This study found that a conditioner containing 18-MEA and SPDA can improve hair's smoothness and reduce flyaways, enhancing hair manageability.
6 citations
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June 1986 in “The Journal of Dermatology” This report discusses a case of reticular erythematous mucinosis syndrome, highlighting minimal mucin deposition and significant lymphocytic infiltration around the hair follicle, contributing to the ongoing debate about its nature as a mucinosis.
This study found that a blend of low- and high-molecular weight hyaluronic acid significantly improved penetration into the hair cortex compared to individual HA types, reducing frizz and increasing hair elasticity and water content, as measured by Confocal Raman Spectroscopy.
December 2025 in “Processes” This study found that minoxidil had the highest solubility in shea butter, stearic acid, and rosemary oil, suggesting these natural oils may improve drug loading and encapsulation efficiency in lipid nanocarrier formulations for potential hair growth applications.
4 citations
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March 2021 in “Journal of Surfactants and Detergents” This study found that hair treated with shampoo containing water-soluble silicone demonstrated smoother sliding and better detangling, compared to shampoo with water-insoluble silicone, due to differences in conditioning film formation.
10 citations
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August 2021 in “Cosmetics” This study identified an optimal sulfate-free and silicone-free conditioning shampoo formulation using 1% hyaluronic acid at 800 kDa, 10% acidic sophorolipid, and 1% sodium chloride, which maintains essential conditioning and cleansing properties without compromising on performance.
67 citations
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February 1983 in “The Journal of Dermatologic Surgery and Oncology” This study suggests that Vigilon®, a new occlusive wound dressing with high water content, may promote better wound healing than other similar dressings in dermatologic surgery.
24 citations
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April 2011 in “Journal of Chemical & Engineering Data” This study measured the solubility of minoxidil in various solvents, finding the highest solubility in methanol and lowest in water, with solubility correlating to temperature.
23 citations
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March 2021 in “Gels” This study found that minoxidil solubilized in gelatin-containing microemulsions resulted in over 5% of the drug remaining in porcine skin, significantly more than the reference gel.
7 citations
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January 2001 in “Comprehensive series in photosciences” This study found that UV stabilizers must diffuse uniformly and in high uptake levels throughout hair fibers during humidification cycles to effectively prevent photo-oxidative degradation.
February 2026 in “ACS Omega” This study developed a multifunctional hydrogel, QTMP-Gel, which significantly accelerated wound healing in an oral mucositis hamster model by providing antioxidant and antibacterial effects, reducing inflammation, and controlling infection.
8 citations
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August 2012 in “Clinical, cosmetic and investigational dermatology” In this study, Doublebase gel was more effective in maintaining and increasing skin hydration compared to Aqueous cream BP, with higher patient satisfaction and preference for future use.
September 2010 in “International Journal of Cosmetic Science” This study describes a microfluorometric method to quantify lipid removal and reattachment on human hair during light exposure and chemical treatments, altering hair surface properties from hydrophobic to hydrophilic.
September 2025 in “Institutional Repositories DataBase (IRDB)” The nanoemulsion system effectively delivers drugs through the skin and shows promise for treating skin conditions.
This article discusses the rising use of low-dose oral minoxidil for androgenetic alopecia and mentions common side effects like hypertrichosis, but provides no new clinical findings.
January 2026 in “Indus journal of bioscience research.” In this study, Hibiscus rosa-sinensis extract was used to formulate and evaluate herbal cosmetic creams for their antioxidant properties, stability, and effectiveness. The formulations demonstrated strong antioxidant potential, stability under various conditions, and favorable cosmetic qualities, suggesting HRS as a beneficial ingredient in skincare products.
44 citations
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October 1989 in “International Journal of Pharmaceutics” This study found that topical minoxidil solutions showed the highest skin permeation at 3-4% concentrations, with crystallization occurring at a 5% concentration due to vehicle component evaporation.
8 citations
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August 1993 in “Colloid & Polymer Science” This study argues that the reported "toughening" transition in keratin is a misinterpretation, actually representing the evaporation peak of residual water in the fibers.
26 citations
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March 2020 in “Antioxidants” This study found that microwave-assisted Opuntia humifusa extract improved antioxidant and anti-inflammatory properties to counteract particulate matter's harmful effects on HaCaT keratinocytes.
October 2022 in “Journal of Kermanshah University of Medical Sciences” The researchers reported that caprylic acid effectively enhances the permeability and diffusion of minoxidil through rat skin compared to other penetration enhancers.
This study found that iontophoresis significantly increased folicular delivery of minoxidil sulfate and sustained release when combined with chitosan microparticles, suggesting potential to reduce application frequency for treating androgenic alopecia.
19 citations
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July 2020 in “Journal of drug delivery science and technology” This study found that nano-sized minoxidil formulations significantly increased skin penetration and follicular drug delivery for alopecia areata treatment, compared to conventional ethanol-based solutions, and demonstrated effective controlled release over six hours.
20 citations
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June 1964 in “Archives of Dermatology” This study described three cases of follicular mucinosis and observed that one case responded rapidly to systemic corticosteroids, suggesting a potential therapeutic effect.
2 citations
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November 1987 in “Archives of Dermatology” This study found that minoxidil was released 50% less from creams than from lotions, with a similar release profile across different lotion formulations, suggesting a specific vehicle composition for topical use.
2 citations
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January 2016 in “Journal of in silico & in vitro pharmacology” This study found that coencapsulating Minoxidil and Rosemary essential oil in liposomes increased Minoxidil's encapsulation efficacy, while Rosemary oil's entrapment was not significantly affected.
January 2020 in “Korean journal of ophthalmology/Korean Journal of Ophthalmology” This study found that minoxidil increases trabecular meshwork cell permeability, possibly via the downregulation of tight junction proteins and the generation of reactive oxygen species.