Development of Delivery Systems for Passive and Iontophoretic Topical Administration of Minoxidil in the Treatment of Androgenic Alopecia

    December 2009
    Guilherme M. Gelfuso
    Studysummary This study found that iontophoresis significantly increased folicular delivery of minoxidil sulfate and sustained release when combined with chitosan microparticles, suggesting potential to reduce application frequency for treating androgenic alopecia.
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    Research cited in this study 16

    1. Targeted Transfollicular Delivery of Artocarpin Extract from Artocarpus Incisus by Means of Microparticles European Journal of Pharmaceutics and Biopharmaceutics · 2007
    2. Effect of Tocopheryl Polyethylene Glycol Succinate on the Percutaneous Penetration of Minoxidil from Water/Ethanol/Polyethylene Glycol 400 Solutions Drug development and industrial pharmacy · 2006
    3. Transfollicular Drug Delivery: Is It a Reality? International journal of pharmaceutics · 2005
    4. Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    5. RU 58841-Myristate Prodrug Development for Topical Treatment of Acne and Androgenetic Alopecia PubMed · 2005
    6. Limitations of Human Occipital Scalp Hair Follicle Organ Culture for Studying the Effects of Minoxidil as a Hair Growth Enhancer Experimental Dermatology · 2004
    7. Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    8. Is Androgenic Alopecia a Result of Endocrine Effects on the Vasculature? Medical Hypotheses · 2003
    9. Safety of Topical Minoxidil Solution: A One-Year, Prospective, Observational Study Journal of Cutaneous Medicine and Surgery · 2003
    10. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    11. Minoxidil and Male-Pattern Alopecia: A Potential Role for a Local Regulator of Sebum Secretion with Vasoconstrictive Effects? Medical Hypotheses · 1999
    12. The Psychosocial Consequences of Androgenetic Alopecia: A Review of the Research Literature British Journal of Dermatology · 1999
    13. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    14. Characterization of Recombinant Human Liver Thermolabile Phenol Sulfotransferase with Minoxidil as the Substrate Biochemical and Biophysical Research Communications · 1995
    15. Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles Journal of Investigative Dermatology · 1990
    16. Quantitative Assessment of 2% Topical Minoxidil in the Treatment of Male Pattern Baldness Clinical and Experimental Dermatology · 1989

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