Temperature-Dependent Phase Transition Microemulsions for Enhanced Transdermal Delivery of Finasteride and Silodosin

    March 2025 in “ Scientific Reports ”
    Hadir F. Marei, Mona F. Arafa, Gamal M. El Maghraby
    Image of study
    TLDR Menthol-based microemulsions improve skin delivery of finasteride and silodosin.
    The study investigates the use of menthol-based microemulsions (MEs) for enhancing the transdermal delivery of finasteride and silodosin, which are used to treat benign prostatic hyperplasia. These MEs undergo temperature-dependent phase transitions, particularly when ethanol is used as a cosurfactant, significantly increasing the transdermal flux of both drugs compared to aqueous solutions. The research confirmed the formation of nanosized droplets and thermoresponsive behavior, which modulated the drugs' thermodynamic activity, resulting in higher delivery efficiency. Despite the high affinity of finasteride to the microemulsion system, the study suggests that thermoresponsive microemulsions are an effective system for the simultaneous delivery of finasteride and silodosin, potentially improving therapeutic outcomes.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 1000+ results
      Taking finasteride and minoxidil

      community Taking finasteride and minoxidil

      in Finasteride  47 upvotes 9 hours ago
      The user has been taking Finasteride for almost 2 months and using Minoxidil 5% spray daily since March. They feel Minoxidil hasn't helped after 7 months, and Finasteride has increased hair loss.
      27M on Finasteride/Minoxidil 8-9 Months, Considering Dutasteride for Hair Loss

      community 27M on Finasteride/Minoxidil 8-9 Months, Considering Dutasteride for Hair Loss

      in Finasteride  71 upvotes 1 week ago
      The user has been using finasteride and minoxidil for 8-9 months without significant improvement in hair loss and is considering switching to dutasteride and topical minoxidil. Another user suggests that dutasteride might be more effective due to its potency and advises patience as hair regrowth can take up to a year.

      community 18M: Side Effects After 3 Months on Topical Finasteride

      in Finasteride  102 upvotes 1 week ago
      An 18-year-old using topical finasteride for hair loss is experiencing side effects like delayed ejaculation and lower sex drive after three months. They are considering whether to continue with the treatment or adjust it, possibly switching back to minoxidil.

      community When should I start using Finasteride (21M)

      in Finasteride  68 upvotes 2 weeks ago
      A 21-year-old male recently had a hair transplant and is considering starting finasteride to prevent further hair loss. Finasteride can be started immediately to maintain existing hair, with potential side effects like decreased libido, and results may take several months.

    Similar Research

    5 / 1000+ results