Temperature-Dependent Phase Transition Microemulsions for Enhanced Transdermal Delivery of Finasteride and Silodosin

The study investigates the use of menthol-based microemulsions (MEs) for enhancing the transdermal delivery of finasteride and silodosin, which are used to treat benign prostatic hyperplasia. These MEs undergo temperature-dependent phase transitions, particularly when ethanol is used as a cosurfactant, significantly increasing the transdermal flux of both drugs compared to aqueous solutions. The research confirmed the formation of nanosized droplets and thermoresponsive behavior, which modulated the drugs' thermodynamic activity, resulting in higher delivery efficiency. Despite the high affinity of finasteride to the microemulsion system, the study suggests that thermoresponsive microemulsions are an effective system for the simultaneous delivery of finasteride and silodosin, potentially improving therapeutic outcomes.