Risk Assessment of the Top 60 Drugs for Drug-Related Sexual Dysfunction: A Disproportionate Analysis from the Food and Drug Administration Adverse Event Reporting System

    August 2025 in “ The Journal of Sexual Medicine ”
    Lihua Wu, Mei Rao, Yang‐Yi Chen, Huiying Wang
    Studysummary This retrospective pharmacovigilance study identified 34 drugs, including finasteride and dutasteride, that may be associated with sexual dysfunction, with a higher risk observed in males aged 31-45.
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    Research cited in this study 6

    1. Exploring Rat Corpus Cavernosum Alterations Induced by Finasteride Treatment and Withdrawal Andrology · 2023
    2. Medications Most Commonly Associated With Erectile Dysfunction: Evaluation Of The Food And Drug Administration National Pharmacovigilance Database Sexual Medicine · 2022
    3. Enduring Sexual Dysfunction After Treatment With Antidepressants, 5α-Reductase Inhibitors, and Isotretinoin: 300 Cases International journal of risk & safety in medicine · 2018
    4. Sexual Dysfunction Related to Drugs: A Critical Review. Part V: Alpha-Blocker and 5-ARI Drugs Pharmacopsychiatry · 2015
    5. Finasteride, Not Tamsulosin, Increases Severity of Erectile Dysfunction and Decreases Testosterone Levels in Men With Benign Prostatic Hyperplasia Hormone Molecular Biology and Clinical Investigation · 2015
    6. Finasteride Drugs · 1999