Most Recent Findings of Curative Drugs for Lower Urinary Tract Symptoms in Clinical Practice

    Yoshihisa Matsukawa, Yasuhisa Funabashi, M Gotou
    Image of study
    TLDR Current treatments for lower urinary tract symptoms include α1-blockers, 5ARIs, PDE5 inhibitors, anticholinergic agents, and β3-adrenergic receptor agonists.
    Current guidelines for treating benign prostatic hyperplasia (BPH) with lower urinary tract symptoms (LUTS) recommended α1-adrenoceptor antagonists (α1-blockers) like tamsulosin and silodosin, 5-alpha-reductase inhibitors (5ARIs) such as dutasteride and finasteride, and phosphodiesterase 5 (PDE5) inhibitors like tadalafil. α1-blockers worked by relaxing the smooth muscle tone of the prostate and bladder neck, while 5ARIs reduced prostate size by inhibiting 5-AR. Tadalafil, the only PDE5 inhibitor approved for LUTS/BPH, improved symptoms by enhancing nitric oxide/cGMP pathway activity, leading to smooth muscle relaxation. For patients with overactive bladder symptoms, anticholinergic agents or β3-adrenergic receptor agonists were also recommended.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 24 results

      community Can i use a dut with tamsulosin?

      in Product  3 upvotes 5 months ago
      The conversation is about using a product containing dutasteride and tamsulosin for hair loss. Users discuss separating the components and potential side effects like frequent urination and changes in libido.

      community 7 years finasteride + 2 year dutasteride - Experience

      in Progress Pictures  15 upvotes 1 year ago
      A 35-year-old started finasteride in 2014 for hair loss and maintained hair density for 7 years, occasionally using ketoconazole shampoo. Switched to dutasteride in 2022 due to increased hair fall, experimented with dosages, and found a combination with tamsulosin effective despite initial adverse reactions.

      community 3.5 years progress. Oral Fin + Topical Min

      in Progress Pictures  19 upvotes 1 year ago
      The user shared a 3.5-year hair loss treatment journey, starting with daily finasteride and oral minoxidil, then switching to finasteride 4 times a week and daily topical minoxidil. After about 2 years and 9 months, they added Dutasteride and Tamsulosin Hydrochloride to their regimen, but reduced the frequency due to side effects, and are currently satisfied with the results.

    Related Research

    1 / 1 results