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Did you mean Phosphodiesterase Inhibitors?

Glossary Phosphodiesterase Inhibitors

block enzymes that break down cyclic nucleotides

Phosphodiesterase Inhibitors (PDE Inhibitors or PDEIs) are a class of drugs that block the action of phosphodiesterase enzymes, which are responsible for breaking down cyclic nucleotides like cAMP and cGMP. By inhibiting these enzymes, PDE inhibitors can increase the levels of these cyclic nucleotides, leading to various therapeutic effects such as vasodilation, anti-inflammatory actions, and improved cardiac function. These drugs are used to treat conditions like erectile dysfunction, pulmonary hypertension, and certain types of heart failure.

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Research

5 / 677 results

research PD59-09 PHOSPHODIESTERASE INHIBITORS COULD REVERSE THE PROLIFERATION OF BPH EPITHELIAL CELLS INDUCED BY CD8+ T CELLS IN LOW ANDROGEN CONDITION

April 2018 in “The Journal of Urology”

This study found that phosphodiesterase inhibitors may suppress the proliferation of benign prostatic hyperplasia epithelial cells by modulating CCL5 levels in low androgen conditions.

research Phosphodiesterase (PDE) Inhibitors for the Treatment of Inflammatory Skin Conditions

January 2018 in “Springer eBooks”

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

Systematic Review of Newer Agents for the Management of Alopecia Areata in Adults: Janus Kinase Inhibitors, Biologics and Phosphodiesterase-4 Inhibitors

research Systematic review of newer agents for the management of alopecia areata in adults: Janus kinase inhibitors, biologics and phosphodiesterase‐4 inhibitors

12 citations , December 2022 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

This review suggests that oral Janus kinase inhibitors are a promising treatment for alopecia areata in adults, showing significant hair regrowth with fewer side effects than conventional treatments, while PDE-4 inhibitors and biologics show limited efficacy.

The Effect of Cilostazol, a Phosphodiesterase 3 (PDE3) Inhibitor, on Human Hair Growth with Dual Promoting Mechanisms

research The effect of cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, on human hair growth with the dual promoting mechanisms

21 citations , April 2018 in “Journal of Dermatological Science”

This study found that topical cilostazol promotes hair growth, enhances hair follicle activities, and may serve as a potential treatment for alopecia.

research Efficacy of the phosphodiesterase-4 inhibitor, apremilast, in a patient with severe alopecia areata

10 citations , August 2019 in “European Journal of Dermatology”

This abstract provides no new clinical results; it discusses the role of surgery and interventional radiotherapy in treating cutaneous squamous cell carcinoma.

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5 / 5 results

community Does caffeine inhibit 5-α-reductase?

4 upvotes 6 years ago

Caffeine may promote hair growth and potentially inhibit 5-α-reductase activity in hair follicles, but its effectiveness and systemic impact remain unclear. Users discuss using topical caffeine solutions, with some experiencing no side effects compared to finasteride.

community Topical caffeine as an adjunct treatment. I think this should be considered.

4 upvotes 3 years ago

Topical caffeine is suggested as a beneficial adjunct treatment for hair growth due to its anti-fibrotic, anti-inflammatory, antioxidant, and other properties. There is skepticism about its effectiveness, especially at low concentrations like in Alpecin liquid.

community Could creatine trigger faster hairloss?

29 upvotes 2 years ago

Creatine is reported by many to increase hair loss, though no scientific evidence supports this. Some use finasteride and minoxidil to manage hair loss, while others avoid creatine due to personal experiences.

community Cardio for more than 60 minutes reduces DHT levels and improve hair growth

in Research/Science 126 upvotes 1 year ago

Long aerobic exercise (over 60 minutes) can reduce DHT levels and improve hair health. Some users discuss using Tadalafil (Cialis) to further reduce DHT after exercise, while others mention using treatments like Minoxidil, Finasteride, and RU58841 for hair growth.

community Someone please offer reassurance

in Minoxidil 3 upvotes 1 month ago

A 19-year-old male is experiencing hair shedding while using oral minoxidil, ketoconazole, dermastamping, and saw palmetto, and is considering switching to finasteride for better results. Users suggest that saw palmetto may not be effective and recommend finasteride instead, while also discussing other treatments like rosemary oil, peppermint oil, and pumpkin seed oil.

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