In Vitro Release of Minoxidil From Topical Formulations

    November 1987 in “ Archives of Dermatology ”
    Dallas Paraskevas
    Image of study
    TLDR Lotions release minoxidil better than creams, with a recommended mix of propylene glycol, water, and ethanol improving effectiveness.
    The study from 1987 investigated the release of minoxidil from different topical formulations and found that lotions released minoxidil more effectively than creams, with creams showing 50% less release. A lotion with a specific ratio of propylene glycol, water, and ethanol (15:15:70) was recommended for topical application, especially when minoxidil is not available in topical form. The study used a Franz diffusion cell for measuring release and HPLC for analysis, concluding that the one-phase system of lotions facilitated better dissolution and release of minoxidil compared to the two-phase system of creams.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community 1 year of treatment + frontal transplant = life-changing results.

      in Progress Pictures  711 upvotes 2 weeks ago
      A 30-year-old shared their successful hair restoration journey using a combination of liposomal topical finasteride and minoxidil, vitamins, and a second hair transplant in Greece, resulting in life-changing improvements without side effects. The user emphasized the importance of proper research for hair transplant clinics and expressed gratitude for finding an effective treatment protocol.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  417 upvotes 6 months ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

      community Crown recovery update - 7 months of treatment

      in Progress Pictures  1034 upvotes 4 months ago
      A 29-year-old reports positive hair recovery after 7 months using liposomal topical finasteride and minoxidil, low-level light therapy, and vitamins, following a 3600 graft DHI procedure. They experienced no side effects from the topical treatment, unlike with oral finasteride.

    Related Research

    1 / 1 results