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This study identified a subtype of itch-sensing neurons in mice, which express Ret and somatostatin, and found that their ablation reduces scratching induced by certain pruritogens.

This review discusses the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles and modern technologies like 3D bioprinting but reports no new clinical results.

This review summarizes the therapeutic potential and development of engineered extracellular vesicles for tissue repair and regenerative medicine, reporting no new clinical findings.

This review discusses the potential of biomimetic synthetic vesicles to advance precision diagnostics and medicine by combining the beneficial properties of naturally occurring extracellular vesicles and synthetic nanoparticles, although no new clinical results are reported.

This study suggests that melanoma tumor cells exhibit intrinsic plasticity, challenging the applicability of the cancer stem cell model to this malignancy.

This review discusses autologous dermis-derived stem cells and their potential in regenerative medicine, summarizing current literature on their niches, characteristics, and applications, but it reports no new experimental results.

This review discusses strategies to improve CRISPR/Cas systems by addressing limitations like off-target effects and delivery inefficiencies, offering practical guidance and highlighting future applications, but reports no new research findings.

This review discusses how using hydrogels as a three-dimensional culture platform for mesenchymal stem cells might affect the production of extracellular vesicles, highlighting challenges in standardization and opportunities to boost EV yield via combined hydrogels and bioreactor methods.

This review discusses the therapeutic potential of mesenchymal stem cell-derived small extracellular vesicles for chronic wound treatment and reports no new clinical results, emphasizing the need for further research on their large-scale production and engineering.

This narrative review explores how exosomes and cell culture-conditioned media are becoming key players in the cosmetic industry for skin rejuvenation and prejuvenation, emphasizing their multifunctional topical benefits and potential future applications.

This review highlights the therapeutic potential of plant-derived exosomes, noting their larger size compared to animal-derived exosomes and usefulness in targeted drug delivery and inter-kingdom communication. It summarizes existing research on their biogenesis, characterization, and engineering for drug delivery, indicating significant opportunities for biotechnological advancements.

This review discusses the advances and challenges of using mesenchymal stem cell-derived extracellular vesicles in therapeutic applications and reports no new clinical findings.

This review discusses the role of extracellular vesicles as therapeutic agents for wound healing and highlights the need for further research into their clinical applications.

This review explores the potential of extracellular vesicle therapy as a novel strategy to delay intervertebral disc degeneration and enhance tissue repair, by modulating key pathogenic mechanisms, with a focus on the molecular components and bioengineering modifications of extracellular vesicles.

This review examines the potential and challenges of extracellular vesicles in cosmetics, noting their transformative impact despite regulatory and production hurdles; it reports no new experimental results.

Researchers demonstrated that a new vaccine platform using antigen-loaded hydrogels enhanced humoral immune responses in mice, producing stronger antigen-specific antibody levels compared to the conventional adjuvant Alum, and offering promising protective capabilities against influenza virus.

This review highlights the promise of small extracellular vesicles (sEVs) as biomarkers for sepsis, emphasizing their potential to improve early detection and guide therapeutic decisions by reflecting the immune status and pathogen presence in patients.

In this research, an optimized protocol was developed for dissociating human scalp tissue to produce high-quality single-cell suspensions suitable for single-cell RNA sequencing, aimed at studying the transcriptomics of human hair follicles.

This study found that using a microwell array device to expand hair follicle stem cells in Matrigel significantly increased cell numbers and enhanced hair regeneration in mice.

D-chiral biomaterial scaffolds enhance tissue and hair regeneration by activating the body's immune system.

This review summarizes how single-cell omics technologies have advanced understanding of cellular regulatory programs in sheep and goats, but highlights limitations in genomic annotation and integration with population genetics for molecular breeding.

In this review, researchers examined advanced sensing technologies and bioelectronic interfaces that could improve understanding of the skin–brain axis, highlighting challenges and strategies for integrating these platforms into models for studying skin and neural interactions.

This study reviews the role of exosomes in regenerative aesthetics, highlighting their potential in treating conditions like photoaging and wound healing through mechanisms like matrix remodeling and immunomodulation, while also noting advancements in exosome isolation techniques and regulatory considerations.

This review reports that exosome-based therapies, coupled with nanotechnology and AI, show promise in aesthetic medicine, notably in skin rejuvenation and hair restoration, but large-scale trials and clearer regulatory frameworks are needed for effective clinical adoption.

This chapter highlights the potential of exosomes as innovative agents in cosmetic dermatology, noting their ability to promote skin rejuvenation and target issues like wrinkles, photoaging, and hair loss.

In this study, the authors identified and characterized the Get3d protein, conserved across plants and photosynthetic bacteria, which localizes to the chloroplast in Arabidopsis thaliana and potentially plays a role in tail-anchored protein targeting, linked to photosynthesis homeostasis.

This review outlines the role of mechanical forces in the development of sensory organs like eyes and ears, emphasizing insights from recent animal studies and microfabricated organoid systems; it presents no new experimental results.

This perspective highlights how advancements in single-cell sequencing and digital pathology can help understand the complex mechanisms of immune responses, fibrosis, and tissue remodeling related to medical implants, aiming to address the challenges of implant-related tissue reactions reported in this study.

This study revealed gene expression patterns in yak hair follicles during different growth phases, enhancing the understanding of cell fate specialization and providing insights for yak villus development.

This study reviews how advancements in nanotechnology have improved food safety, nutrition delivery, and health interventions, but it also highlights the need for more research into safety evaluations and regulatory concerns.