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This study found that valproic acid-loaded microemulsion formulations enhanced skin penetration pathways in guinea pigs compared to an aqueous solution, with composition elements like oil content and surfactant ratios significantly affecting drug delivery performance.

In animal studies, this research found that minoxidil-loaded air-pocket microneedles improved hair loss treatment efficiency compared to topical application, while effectively sealing punctured skin openings.

This study found that a biocomposite microneedle system, which includes selenium nanozyme and hypoxic extracellular vesicles, enhanced hair density and follicle diameter in androgenetic alopecia mice by fighting inflammation, promoting blood vessel growth, reducing reactive oxygen species, and counteracting androgen effects.

This study found that Imaging Mass Cytometry effectively visualizes multiple biomarkers in alopecia areata, enhancing analysis of immune cell and tissue interactions in hair pathology.

This study found that nanostructured lipid carriers enhanced the skin penetration and retention of minoxidil compared to solid lipid nanoparticles, suggesting they could be a promising method for topical delivery.

This study found that combining laser ablation with nanoparticulate drug formulations effectively enhanced the skin and follicular delivery of hydrophilic drugs like minoxidil and minocycline in preclinical models.

In this study, researchers developed a drug-free microneedle patch using chitosan lactate and stem cell-derived exosomes that significantly promotes hair regeneration in animal tests compared to minoxidil, highlighting its potential as a simple and efficient hair loss treatment.

In this study, melatonin-loaded Pickering emulsions stabilized by chitosan-dextran sulphate nanoparticles and enhanced with lecithin showed improved photostability, antioxidant activity, and follicular delivery in androgenic alopecia-affected rats, potentially rivaling commercial minoxidil for hair loss treatment.

This study found that coencapsulating Minoxidil and Rosemary essential oil in liposomes increased Minoxidil's encapsulation efficacy, while Rosemary oil's entrapment was not significantly affected.

In this study, a pH-responsive microneedle patch was developed, showing potential in rat models for treating spinal cord injuries by reducing inflammation, promoting nerve regeneration, and supporting neurogenesis, which contributed to improved motor and neurological recovery.

This study observed that a peptide showed higher antioxidant and metal ion chelation activity compared to its encapsulated version cross-linked in calcium alginate beads.

This study reported that meloxicam-loaded spanlastics, created using the ethanol injection method, demonstrated potential as a drug delivery system with sustained release and effective entrapment efficiency.

This study reviewed preclinical and clinical research and found that AFL-assisted topical drug delivery is considered safe and effective, enhancing drug efficacy, reducing treatment time and pain, and improving cosmetic and safety outcomes, but larger clinical trials are needed to confirm these benefits.

This study found that polymeric micelle formulations significantly improved the targeted delivery of adapalene to hair follicles compared to standard Differin® products, which suggests potential advantages in treating hair follicle-related conditions and reducing side effects.

This preclinical study observed that a nanoencapsulated ingredient complex, AcPi, may prevent hair follicle aging and hair loss by reducing oxidative stress, enhancing mitochondrial activity and WNT/β-catenin signaling, and controlling androgenic metabolism when tested on human scalp cultures.

This study found that MSN-ceria nanomaterial accelerates cutaneous wound healing in rat models by reducing ROS levels and promoting collagen deposition, leading to improved tissue regeneration without significant scarring.

In this study, synthesized composite nanocarriers containing ribose and peptides demonstrated enhanced transdermal delivery, improved uptake by skin cells, promoted cell proliferation, enhanced antioxidant enzyme activities, and increased autophagy, suggesting a potential for more effective skin anti-aging treatments.

This study found that PBMCsec has anti-fibrotic effects on mouse and human skin scars by regulating pro-fibrotic gene expression and inhibiting myofibroblast differentiation and elastic fiber breakdown.

This review explores the potential, challenges, and recent advancements of dissolving microneedles in drug delivery, summarizing their varied applications and current limitations without providing new clinical results.

This study found that combining CelluTome system and RCM is a safe and effective protocol for evaluating wound healing responses in patients with epidermolysis bullosa.

This study found that smaller curcumin nanocrystals (60 nm) enhanced transdermal and transfollicular penetration more effectively than larger sizes, influenced by particle size.

This study developed cilostazol-loaded formulations for nose-to-brain delivery, finding that these formulations improved cilostazol's bioavailability by enhancing solubility, absorption, and permeability, achieving nearly 100% drug release in vitro within 2 hours.

In this study, injectable microdepots containing rapamycin and poly(lactic-co-glycolic acid) were developed and demonstrated to effectively promote hair regrowth in mice by sustaining drug release and inducing anagen phase transition in hair follicles through modulating autophagy and the Wnt/β-catenin pathway.

This case report describes the unexpected hair repigmentation surrounding a scalp tumor in a 74-year-old man, suggesting a potential link between the carcinoma and changes in hair pigmentation.

This study reported the presence of dermatophyte macroconidia directly in clinical samples from a 3-year-old boy with tinea capitis, marking the first time this has been documented. The infection, caused by Microsporum ferrugineum, was successfully treated with systemic itraconazole and topical ketoconazole shampoo.

This report discusses a case of reticular erythematous mucinosis syndrome, highlighting minimal mucin deposition and significant lymphocytic infiltration around the hair follicle, contributing to the ongoing debate about its nature as a mucinosis.

A new treatment using special microneedles and a nitric oxide-releasing drug could improve hair growth and be more convenient for people with hair loss.