December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This study tested the acute toxicity of Ficus platyphylla methanol leaf extract in Wistar rats and found no mortality or significant liver enzyme changes at doses up to 5000 mg/kg, suggesting a high margin of acute safety and supporting its traditional use under short-term exposure.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that the methanol leaf extract of Ficus platyphylla demonstrated a high margin of acute safety in Wistar rats, showing minimal risk under short-term exposure with no mortality at doses up to 5000 mg/kg and no significant changes in liver enzyme activities.
In this study, the ethanol extract of Tridax procumbens leaves exhibited antimicrobial activity against both Gram-positive and Gram-negative bacteria, with specific active compounds identified through GC-MS analysis that may contribute to its therapeutic potential.
January 2021 in “Natural Products Chemistry & Research” This study found that Datura metel leaf and flower extracts could improve hair growth, with leaf extracts prompting quicker growth and mixed extracts enhancing overall regrowth effectiveness in animal models.
April 2022 in “Molecules” This study identified two potent 5α-reductase inhibitors from Tectona grandis leaves, and suggests that ethanol is a preferable solvent for extracting these compounds, which are potential ingredients for hair loss treatments.
8 citations
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September 2016 in “Asian journal of beauty & cosmetology” In this study, the methanol-ultrasound extract of Dendropanax morbifera leaf showed potential for use in functional cosmetics and hair growth products due to its high antioxidant capacity and effects on growth factor expression without cytotoxicity.
1 citations
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October 2021 in “Jundishapur Journal of Natural Pharmaceutical Products” This study found that methanolic extract of Ficus carica leaves induced apoptosis and inhibited proliferation in B16F10 melanoma cells, suggesting potential anti-cancer properties for further investigation in melanoma.
This study found that a 10% hibiscus leaf extract hair tonic demonstrated better hair growth activity than 2% minoxidil in rabbits but caused eye irritation.
July 2019 in “Majalah Obat Tradisional” This study reported that a 4% water fraction of green tea leaf extract showed the most effective hair growth promotion in rabbits.
4 citations
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September 2022 in “Indian Journal of Pharmaceutical Education and Research” This study found that methanolic leaf extract of Plumbago zeylanica L. demonstrates strong thrombolytic and antioxidant activities and shows promise as a source of such agents.
11 citations
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August 2022 in “Evidence-based Complementary and Alternative Medicine” This study found that methanolic extract of Eclipta alba leaves exhibited strong antibacterial effects against certain pathogens including methicillin-resistant Staphylococcus aureus, but it showed no activity against Mycobacterium tuberculosis, including drug-resistant strains.
2 citations
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May 2025 in “Antioxidants” This study examined the phytochemicals and antioxidant activities of methanolic extracts from Cameroonian Prunus africana bark and Leea indica and Paullinia pinnata leaves, identifying various phenolic compounds and significant antioxidant properties through multiple assays.
This study found that ethanolic extract and fractions of Ceiba leaf tonic may enhance rabbit hair growth similarly to 2% minoxidil.
2 citations
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February 2021 in “IOP Conference Series Earth and Environmental Science” This study identified that Mangkokan leaf extracts contain active compounds such as alkaloids, flavonoids, steroids, tannins, phenols, and saponins, using different solvents and FTIR analysis.
December 2023 in “Polish Journal of Chemical Technology” This study found that Ajuga reptans leaf and root extracts, when incorporated into cosmetic products, improved skin hydration, elasticity, pore size, hyperpigmentation, and wrinkle depth.
2 citations
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January 2023 in “International Journal of Dermatology Research” This study reported that C. procera leaf extracts showed antifungal activity against several dermatophytes, with ethanol extracts demonstrating slightly greater efficacy than aqueous extracts.
September 2023 in “Ethiopian journal of health sciences” This study evaluated the effects of dry plantain leaf extract on mice infected with Plasmodium berghei, finding that the extract reduced liver oxidative stress associated with the infection.
June 2023 in “jurnal veteriner” In this study, Typhonium flagelliforme leaf-ethanolic extract combined with natural interferon was observed to stabilize body weight, inhibit tumor growth, and reduce mitosis, angiogenesis, and certain protein expressions in carcinogen-induced tumors in female mice, suggesting potential antitumor effects.
December 2019 in “International journal of engineering applied science and technology” This review discusses the traditional uses of Tridax procumbens for wound healing, antifungal, and antibacterial purposes, but reports no clinical findings.
2 citations
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September 2022 in “Advances in Environmental Biology” This study found that ethanolic extracts of Avicennia marina leaves showed potential antibacterial activity against Vancomycin-Resistant Enterococcus faecium but were less effective than standard antibiotics.
44 citations
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January 2007 in “Biological & pharmaceutical bulletin” This study found that Piper nigrum leaf extract showed in vivo anti-androgenic activity and potent 5α-reductase inhibitory effects, with piperine and (−)-cubebin identified as active components.
May 2026 in “Global Translational Medicine” This study found that ethanol extract of Syzygium aromaticum (clove) leaves significantly improved lipid profiles and increased body weight in testosterone-induced benign prostatic hyperplasia rats, suggesting potential anti-hyperlipidemic effects and modulation of body weight through metabolic activity.
April 2026 in “Inflammopharmacology” This study found that Punica granatum ethanolic leaf extract may alleviate skin fibrosis in rats by modulating inflammation-related pathways and reducing dermal alterations.
September 2025 in “Molecules” This study found that Camellia oleifera leaf extracts, especially the 50% ethanolic extract, have significant antioxidant activity and may offer promising bioactive compounds for cosmetic and pharmaceutical uses.
11 citations
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March 2023 in “Life” This study found that the aerial parts (leaves and flowers) of Scorzonera undulata from southwest Tunisia demonstrated higher antioxidant activity and beneficial biological properties compared to its tubers.
May 2025 in “Baghdad Journal of Biochemistry and Applied Biological Sciences” In laboratory and animal studies, this research found that the ethanolic leaf extract of Adiantum capillus-veneris demonstrated a range of biological activities, including antibacterial, antifungal, antioxidant, anti-inflammatory, antidiabetic, wound-healing, anticancer, and antidiarrheal effects, suggesting its potential for various therapeutic applications.
May 2021 in “Austin journal of pharmacology and therapeutics” This study explores the medicinal and environmental applications of Physalis species, highlighting the wound healing properties of Physalis angulata L. and the antibacterial and antitumor activities of its fruit extracts.
May 2025 in “Tropical Natural History” In this study, Zingiber junceum Gagnep. is documented for the first time as a species in Vietnam, and its micro-morphological traits and the phytochemical profiles of its various extracts are detailed, highlighting the presence of several bioactive compounds.
16 citations
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April 2017 in “Journal of Cosmetic Dermatology” This study found that fig leaf extract significantly downregulated inflammatory and androgenic gene expression in vitro, suggesting potential topical benefits for certain skin disorders.
February 2024 in “Trends in Sciences” This study examined the stability of two 5α-reductase inhibitors in Tectona grandis extracts, finding that they are more stable in acidic environments and degrade rapidly under heat and light unless protected, suggesting the need for careful storage when developing anti-hair loss medications.