Effects of Solvent System and Storage Condition on Chemical Stability of 5α-Reductase Inhibitor Compounds in Tectona Grandis Leaf Extracts

    February 2024 in “ Trends in Sciences ”
    Kamonlak Insumrong, Neti Waranuch, Kornkanok Ingkaninan, Nutchaninad Tanuphol, Wudtichai Wisuitiprot, Eakkaluk Wongwad, Ngamrayu Ngamdokmai, Nungruthai Suphrom
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    TLDR Store Tectona grandis leaf extracts in slightly acidic, light-protected conditions for best stability.
    This study investigated the stability of two 5α-reductase inhibitors, (+)-eperua-8,13-dien-15-oic acid and (+)-eperua-7,13-dien-15-oic acid, found in Tectona grandis leaf extracts under various conditions. The stability was tested in different solvent systems, pH levels, temperatures, and light exposures using HPLC analysis. The compounds were more stable in acidic solutions and degraded faster in neutral or basic environments, with light exposure particularly affecting compound 1. High temperatures also accelerated degradation, but the presence of PG helped minimize this when light was excluded. The calculated shelf-life of the extracts was 1.48 years, suggesting that they should be stored in non-aqueous or slightly acidic solutions with light protection. This information is valuable for developing future anti-hair loss medications.
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