Comprehensive Evaluation of Tectona Grandis L.f.: Integrated In Vitro and In Silico Analysis of Steroid 5α-Reductase Inhibition and Anti-Inflammatory Properties

    November 2025 in “ ACS Omega ”
    Sasimontra Timjan, Kowit Hengphasatporn, Janjira Inprasit … Prapapan Temkitthawon
    Studysummary This study found that compounds from *Tectona grandis* leaves showed moderate inhibition of steroid 5α-reductase, a factor in androgenetic alopecia, and exhibited anti-inflammatory properties by inhibiting nitric oxide and pro-inflammatory cytokines IL-1β and IL-6 in vitro, suggesting potential dual-action benefits for AGA management.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on pubs.acs.org →
    Discuss this study in the Community →

    Research cited in this study 15

    1. Geographic Influence and Metabolomics-Driven Discovery of 5-Alpha Reductase Inhibitors in Tectona Grandis L.f. (Teak) Leaves Molecules · 2025
    2. Computational Drug Discovery of Potential 5α-Reductase Phytochemical Inhibitors and Hair Growth Promotion Using In Silico Techniques Frontiers in Bioinformatics · 2025
    3. Exploring the Inhibitory Potential of Phytosterols Beta-Sitosterol, Stigmasterol, and Campesterol on 5-Alpha Reductase Activity in the Human Prostate: An In Vitro and In Silico Approach Plants · 2024
    4. 18-β-Glycyrrhetinic Acid Promotes Hair Growth by Stimulating the Proliferation of Dermal Papilla Cells and Outer Root Sheath Cells, and Extends the Anagen Phase by Inhibiting 5α-Reductase Biological and Pharmaceutical Bulletin · 2024
    5. Effectiveness and Safety of Hair Growth Formulation Containing Tectona Grandis L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia Journal of Evidence-Based Integrative Medicine · 2024
    6. Isolation and HPLC Quantitative Determination of 5α-Reductase Inhibitors from Tectona Grandis Leaf Extract Molecules · 2022
    7. Effects of Acanthus Ebracteatus Vahl Extract and Verbascoside on Human Dermal Papilla and Murine Macrophage Scientific Reports · 2022
    8. Structure of Human Steroid 5α-Reductase 2 with the Anti-Androgen Drug Finasteride Nature Communications · 2020
    9. Inhibition of 5α-Reductase, IL-6 Secretion, and Oxidation Process of Equisetum Debile Extract as Functional Food and Nutraceutical Ingredients Nutrients · 2017
    10. A New Label-Free Screen for Steroid 5α-Reductase Inhibitors Using LC-MS Steroids · 2016
    11. Determination of the Potency of a Novel Saw Palmetto Supercritical CO2 Extract for 5α-Reductase Isoform II Inhibition Using a Cell-Free In Vitro Test System Research and reports in urology · 2016
    12. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    13. Finasteride in the Treatment of Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2004
    14. Androgenetic Alopecia and Microinflammation International Journal of Dermatology · 2000
    15. Interleukin-1β-Induced Inhibition of Hair Growth In Vitro Is Mediated by Cyclic AMP Journal of Investigative Dermatology · 1997