Comprehensive Evaluation of Tectona Grandis L.f.: Integrated In Vitro and In Silico Analysis of Steroid 5α-Reductase Inhibition and Anti-Inflammatory Properties

November 2025 in “ ACS Omega ”

Sasimontra Timjan, Kowit Hengphasatporn, Janjira Inprasit, Kornkanok Ingkaninan, Yasuteru Shigeta, Nutchaninad Tanuphol, Prapapan Temkitthawon

TLDR Teak leaf extract may help hair growth and reduce inflammation safely.

The study explores the potential of Tectona grandis (teak) leaf extract as a treatment for androgenic alopecia (AGA) by examining its ability to inhibit steroid 5α-reductase and reduce inflammation. Through in vitro and in silico analyses, the extract and its isolated diterpene compounds showed significant 5α-reductase inhibitory activity and anti-inflammatory properties, including the reduction of nitric oxide and pro-inflammatory cytokines IL-1β and IL-6. The findings suggest that T. grandis leaf extract could serve as a mild hair growth promoter with a favorable safety profile compared to existing treatments like finasteride and minoxidil. However, further research is needed to fully understand its in vivo pharmacokinetics and therapeutic efficacy.

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