This study found that teak leaf extract can be effective in promoting hair growth in males with androgenic alopecia; however, significant variability in steroid 5-alpha reductase inhibitory activity among samples from different geographic origins means quality control is important for consistent therapeutic potential.
May 2025 in “Frontiers in Bioinformatics” This study used computational methods to identify six molecules, with jamogenin being particularly promising, that effectively bind to and inhibit the enzyme linked to male pattern hair loss, suggesting these compounds could be explored further for hair growth potential.
12 citations
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November 2024 in “Plants” This study found that the phytosterols β-sitosterol, stigmasterol, and campesterol have low-to-negligible inhibitory activity against steroidal 5α-reductase type 2 compared to the synthetic inhibitor dutasteride, with β-sitosterol showing the highest activity among the tested phytosterols.
July 2024 in “Biological and Pharmaceutical Bulletin” This study found that 18-β-Glycyrrhetinic acid, a licorice component, stimulated human hair follicle cell proliferation, inhibited testosterone 5α-reductase, and suppressed TGF-β1, suggesting potential for treating androgenetic alopecia by promoting hair growth and prolonging the anagen phase.
March 2024 in “Journal of Evidence-Based Integrative Medicine” This study found that a hair tonic containing 1% teak leaf extract significantly increased hair growth and user satisfaction in men with androgenic alopecia after 24 weeks, without causing adverse effects, and was comparable to the standard treatment, minoxidil.
April 2022 in “Molecules” This study identified two potent 5α-reductase inhibitors from Tectona grandis leaves, and suggests that ethanol is a preferable solvent for extracting these compounds, which are potential ingredients for hair loss treatments.
7 citations
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January 2022 in “Scientific Reports” This study found that Acanthus ebracteatus extract and verbascoside induced dermal papilla cell proliferation and reduced inflammatory cytokine release in vitro, suggesting potential for anti-hair loss applications.
30 citations
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October 2020 in “Nature Communications” This study provides the first crystal structure of the human SRD5A2 enzyme, revealing key insights into its function and inhibition which may aid future drug development.
49 citations
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October 2017 in “Nutrients” This study observed that the ethyl acetate extract of Equisetum debile showed high activity against 5α-reductase and lipid peroxidation with no cytotoxicity on dermal papilla cells.
15 citations
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October 2016 in “Steroids” This study developed and validated a label-free assay using LC-MS to screen for S5αR inhibitors, identifying Thai herbal extracts, Impatiens balsamina L. and Curcuma longa L., as promising sources.
3 citations
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April 2016 in “Research and reports in urology” In a cell-free test setting, this study found that a novel saw palmetto extract effectively inhibited the 5α-reductase type II enzyme, showing promising bioactivity comparable to finasteride for promoting prostate health.
173 citations
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September 2011 in “Journal of Investigative Dermatology” IL-6 contributes to hair loss by shortening the growth phase and causing hair follicles to regress.
62 citations
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April 2004 in “Expert Opinion on Pharmacotherapy” This article reviews the use of finasteride for treating male pattern hair loss, highlighting its mechanism of action in reducing DHT and noting its safety profile with some common adverse effects.
131 citations
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August 2000 in “International Journal of Dermatology” Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.
33 citations
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January 1997 in “Journal of Investigative Dermatology” Interleukin-1β stops hair growth by increasing cyclic AMP levels.
