18-β-Glycyrrhetinic Acid Promotes Hair Growth by Stimulating the Proliferation of Dermal Papilla Cells and Outer Root Sheath Cells, and Extends the Anagen Phase by Inhibiting 5α-Reductase

    Kenta Hagiwara, Akinori Kiso, Shogo Ono, Hiroaki Kitamura, H Yamanishi, Yuki Tsunekawa, Tokuro Iwabuchi
    Image of study
    TLDR Licorice extract helps hair growth and may treat hair loss.
    18-β-Glycyrrhetinic acid, derived from licorice, promotes hair growth by stimulating the proliferation of dermal papilla cells and outer root sheath cells from human hair follicles. It inhibits testosterone 5α-reductase with an IC50 of 137.1 µM, reducing the conversion of androgen to dihydroandrogen. Additionally, it suppresses TGF-β1 expression, potentially prolonging the anagen phase of the hair cycle. These findings suggest that 18-β-Glycyrrhetinic acid could be an effective treatment for androgenetic alopecia.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 1000+ results

    Related Research

    3 / 3 results