Exploring the Inhibitory Potential of Phytosterols Beta-Sitosterol, Stigmasterol, and Campesterol on 5-Alpha Reductase Activity in the Human Prostate: An In Vitro and In Silico Approach

    November 2024 in “ Plants ”
    Mădălina-Georgiana Buț, Amelia Tero-Vescan, Amalia Puşcaş … Gabriel Marc
    Studysummary This study found that the phytosterols β-sitosterol, stigmasterol, and campesterol have low-to-negligible inhibitory activity against steroidal 5α-reductase type 2 compared to the synthetic inhibitor dutasteride, with β-sitosterol showing the highest activity among the tested phytosterols.
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    Research cited in this study 12

    1. Virtual Insights into Natural Compounds as Potential 5α-Reductase Type II Inhibitors: A Structure-Based Screening and Molecular Dynamics Simulation Study Life · 2023
    2. Docking and Molecular Dynamics Identify Leads Against 5 Alpha Reductase 2 for Benign Prostate Hyperplasia Treatment Journal of Chemistry · 2023
    3. Bioactive Metabolites of Edible Mushrooms Efficacious Against Androgenic Alopecia: Targeting SRD5A2 Using Computational Approach Journal of Herbal Medicine · 2022
    4. Identification of Beta-Sitosterol and Stigmasterol as Possible Inhibitors of 5 Alpha-Reductase 1: An In-Silico Study Precision medicine and clinical omics · 2022
    5. Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2 Biology · 2021
    6. Structure of Human Steroid 5α-Reductase 2 with the Anti-Androgen Drug Finasteride Nature Communications · 2020
    7. Screening of Euphorbiaceae Plant Extracts for Anti-5α-Reductase Activity Biological & Pharmaceutical Bulletin · 2018
    8. A New Label-Free Screen for Steroid 5α-Reductase Inhibitors Using LC-MS Steroids · 2016
    9. Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus Acutissima Cortex Evidence-based Complementary and Alternative Medicine · 2015
    10. Development of a New Gas Chromatography–Mass Spectrometry Methodology for the Evaluation of 5α-Reductase Activity Talanta · 2013
    11. Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-Diene or 4,6-Diene 20-Ones and 4-Azasteroid 20-Oximes Molecules · 2011
    12. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011