Traditional Uses, Phytochemistry, Pharmacology, Toxicity and Clinical Application of Traditional Chinese Medicine Cynoglossum Amabile: A Review
April 2024
in “
Frontiers in pharmacology
”
Studysummary This review of Cynoglossum amabile, a traditional Chinese and ethnomedicine, provides insights into its uses, chemical components, biological activities, and toxicity. Highlighting its market potential, the study underscores the importance of indigenous knowledge in drug development despite noted hepatotoxic risk linked to its pyrrolizidine alkaloids.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Cynoglossum amabile, a traditional Chinese medicine, has been used for centuries to treat various ailments such as malaria, hepatitis, and fractures. This review compiles its traditional uses, phytochemistry, pharmacology, and toxicity. The plant contains 47 chemical components, including pyrrolizidine alkaloids (PAs), which have shown anti-inflammatory, anti-tumor, and anti-microbial activities. However, its hepatotoxicity, linked to PAs, raises safety concerns. Preliminary studies suggest potential in treating prostate diseases and alopecia, but further research is needed. The review underscores the importance of indigenous knowledge in drug development and highlights the plant's market potential.
