Docking and Molecular Dynamics Identify Leads Against 5 Alpha Reductase 2 for Benign Prostate Hyperplasia Treatment

    March 2023 in “ Journal of Chemistry ”
    Selina Ama Saah, Patrick O. Sakyi, David Adu-Poku … Kojo Ayittey
    Studysummary This study identified ten novel compounds that may effectively target steroid 5 alpha-reductase 2 (5αR-2) for potential treatment of benign prostate hyperplasia, exhibiting comparable binding energies to existing drugs like finasteride and dutasteride.
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    Research cited in this study 8

    1. Structure of Human Steroid 5α-Reductase 2 with the Anti-Androgen Drug Finasteride Nature Communications · 2020
    2. Efficacy and Side Effects of Drugs Commonly Used for the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia Frontiers in Pharmacology · 2020
    3. Prospective Randomized Study of Sexual Function in Men Taking Dutasteride for the Treatment of Androgenetic Alopecia Journal of Dermatology · 2018
    4. Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-Analysis Acta dermato-venereologica · 2018
    5. Sexual Dysfunction in Subjects Treated with Inhibitors of 5α-Reductase for Benign Prostatic Hyperplasia: A Comprehensive Review and Meta-Analysis International Journal of Andrology · 2017
    6. Dutasteride in Androgenetic Alopecia: An Update Current Clinical Pharmacology · 2017
    7. Comparison of Clinical Trials with Finasteride and Dutasteride PubMed · 2004
    8. Finasteride Drugs · 1999

    Related research 2

    1. Luncheon Symposium: Update on the Efficacy and Safety of Dutasteride in the Management of Androgenetic Alopecia 프로그램북(구 초록집) · 2015
    2. Role of 5α-Reductase Inhibitors in Benign Prostatic Diseases Prostate cancer and prostatic diseases · 2012