In Vitro Skin Penetration of 5α-Reductase Inhibitors from Tectona Grandis Leaf Extracts

    March 2025 in “ Molecules ”
    Kamonlak Insumrong, Neti Waranuch, Kornkanok Ingkaninan, Nutchaninad Tanuphol, Abhay Prakash Mishra, Wudtichai Wisuitiprot, Eakkaluk Wongwad, Ngamrayu Ngamdokmai, Nungruthai Suphrom
    TLDR Tectona grandis leaf extracts, especially with propylene glycol, may be promising for topical hair loss treatments.
    The study examined the in vitro skin penetration of two 5α-reductase inhibitors from Tectona grandis leaf extracts, focusing on their potential for hair loss treatments. Using the Franz diffusion cell model, it was found that compound 1 had significantly higher skin penetration than compound 2, attributed to its greater hydrophobicity. Both compounds showed poor solubility in water but improved solubility in HEPES buffer with 2% Tween 20, and their penetration was enhanced by propylene glycol (PG). After 24 hours, compound 1 achieved a penetration of 12.72% in PG, while compound 2 reached 11.30%. These findings suggest that T. grandis extracts, especially with PG, could be promising for developing topical hair loss treatments.
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