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This review discusses the role and therapeutic potential of mesenchymal cell-derived exosomes in organ development and disease treatment, highlighting their application in cell-free therapeutic strategies and current challenges faced in their use.

This study found that organoid cultures of human epithelial and mesenchymal cells can produce hair peg-like structures, and their growth is enhanced by minoxidil, suggesting potential for hair drug screening.

In this research, the authors identify coordinated mechanical forces as crucial for hair follicle development in mammals, with contractile, proliferative, and proteolytic activities facilitating the formation and sectioning of epithelial structures crucial for forming a functional tissue.

This study reports that transplantation and in vivo reprogramming using specific reprogrammed cell types can generate skin appendage-like structures in adult mice, suggesting potential therapeutic avenues for skin regeneration and disorders.

This review highlights the importance of using 3D scaffolds in vitro to support hair follicle regeneration, emphasizing how these structures help maintain cell function and mimic the natural environment, which is crucial for developing hair follicle organoids for transplantation.

This study found that a newly created biomimetic microneedle platform effectively expedited wound repair in diabetic animal models by reducing inflammation, enhancing angiogenesis, and promoting skin regeneration through targeted drug delivery and immune response modification.

This study reported that the concept of the onychodermis, defined by CD10 expression, is present in the developing nail organ and may play a role in nail plate formation.

This study found that mesenchymal cells in mouse and chicken embryonic skin undergo a process of migration driven by tissue tension and WNT secretion, influencing their dispersal and integration into dermal condensates.

In this study, KC-AD-MSCs were found to increase COL7 deposition and anchoring fibril formation at the dermal-epidermal junction in a RDEB mouse model, suggesting potential for improving skin integrity in recessive dystrophic epidermolysis bullosa patients.

This review emphasizes the importance of understanding hair follicle embryology, anatomy, and the hair cycle to effectively diagnose and treat hair disorders like alopecia.

In this review, researchers summarized findings from clinical studies on mesenchymal stem cells for diabetes treatment, noting their potential but also highlighting challenges like small sample sizes and the need for standardization in preparation and delivery methods.

This study found that specialized nipple epidermis in mice is maintained by the repression of TGFβ signaling through estrogen, which highlights the role of hormonal regulation in epidermal maintenance.

In this study, subcutaneous injection of mesenchymal stem cell-conditioned medium promoted regeneration of mice skin aged by D-galactose, improving skin thickness, vascularization, and collagen density.

This study reports that different adhesion molecules play distinct roles in the morphogenesis of feathers and hair, influencing processes such as mesenchymal condensation, epithelial folding, and cell death.

This study in adult male albino rats reported that human umbilical cord blood-derived mesenchymal stem cells were more effective than minoxidil in promoting hair growth for androgenic alopecia, observing superior outcomes in hair follicle metrics.

This study found that canine adipose-derived mesenchymal stem cell-derived dermal papilla-like tissues promoted new hair follicle formation and increased vascularization in mice, suggesting potential for hair regeneration.

This review examines the location and markers of hair follicle stem cells, finding that they are primarily located in the bulge region and can contribute to various skin structures, but challenges remain in distinguishing them from their progeny.

The study concluded that local administration of in-vitro-expanded bone marrow-derived mesenchymal stem cells accelerates and promotes healing in full-thickness excisional wounds in adult male albino rats.

This study found that dermal papilla-like tissues derived from canine adipose stem cells promoted new hair follicle formation and increased vascularization in athymic nude mice.

This review discusses various approaches to treating alopecia, including drug therapy and hair transplantation, but reports no new research findings; the authors highlight the need for novel techniques like cell culturing.

This review explores recent insights into the diverse cell populations involved in skin development, homeostasis, wound healing, and cancer progression but reports no new results.

This chapter reviews the anatomy and physiology of hair follicles but reports no new research findings or clinical results.

This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.

In this study, researchers found that human fingerprint ridges are formed through a modified hair follicle developmental process and spatial patterns influenced by specific signaling pathways.

This review discusses hair follicle organoids as emerging models for studying hair biology and disorders, emphasizing their promise for bridging basic research and clinical applications, but reports no new results.

This article reviews the role of epithelial-mesenchymal interactions in hair follicle development and discusses the challenges of understanding the signals that regulate this complex process; it reports no new results.

This study suggests that interfollicular epidermal keratinocytes with stem-like features may serve as an alternative to follicular keratinocytes for hair regeneration by supporting hair follicle morphogenesis in vivo.

This review discusses recent advancements and ongoing challenges in engineering human skin with appendages using scaffold-free and scaffold-based bioengineering approaches, but it reports no new clinical results.

This review discusses the molecular mechanisms and clinical applications of autologous platelet-derived products for TMJ regeneration, but reports no new clinical results.

This review discusses the roles and characteristics of skin stem cells, their niches, and signaling pathways in skin maintenance, aging, and cancer, highlighting their potential in therapeutic applications but presenting no new clinical findings.