Histological and Molecular Restoration of Type VII Collagen in Recessive Dystrophic Epidermolysis Bullosa Mouse Skin by Topical Injection of Keratinocyte-Like Cells Differentiated from Human Adipose-Derived Mesenchymal Stromal Cells

    Akinori Matsuda, Toshio Hasegawa, Yuri Ikeda … Shigaku Ikeda
    Studysummary In this study, KC-AD-MSCs were found to increase COL7 deposition and anchoring fibril formation at the dermal-epidermal junction in a RDEB mouse model, suggesting potential for improving skin integrity in recessive dystrophic epidermolysis bullosa patients.
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    Research cited in this study 3

    1. Regenerative Capacity of Adipose-Derived Stem Cells Compared with Mesenchymal Stem Cells International Journal of Molecular Sciences · 2019
    2. Stem Cell Dynamics, Migration, and Plasticity During Wound Healing Nature Cell Biology · 2018
    3. Adipose-Derived Stromal Cells in Regenerative Medicine: A Review World Journal of Stem Cells · 2017