Effect of Mesenchymal Stem Cells in Androgenic Induced Alopecia in Adult Male Albino Rats Versus Conventional Minoxidil Treatment

    October 2024 in “ QJM ”
    Hussein M. Ali, Khaled Hamdy, Nagwa Ebrahim El- Nefiawy, Sherif A. Kamar, Marwa A. Fetouh
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    The study investigated the effects of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) compared to conventional minoxidil treatment on androgenic alopecia (AGA) in 48 adult male albino rats. Results showed that stem cell therapy was more effective than minoxidil in treating AGA, as evidenced by changes in hair follicle dynamics, including a decrease in terminal hair number and an increase in vellus hair. Additionally, there were structural changes such as cavitations in hair and sheaths, collagen fiber deposition, and thinning of the arrector pili muscle. Overall, stem cell therapy demonstrated superior efficacy in promoting hair growth in AGA.
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