Effect of Mesenchymal Stem Cells in Androgenic Induced Alopecia in Adult Male Albino Rats Versus Conventional Minoxidil Treatment

October 2024 in “ QJM ”

Hussein M. Ali, Khaled Hamdy, Nagwa Ebrahim El- Nefiawy, Sherif A. Kamar, Marwa A. Fetouh

mesenchymal stem cells human umbilical cord blood-derived mesenchymal stem cells minoxidil androgenic alopecia hair follicle dynamics vellus hair terminal hair collagen fiber deposition arrector pili muscle stem cell therapy Rogaine AGA

TLDR Stem cell therapy is more effective than minoxidil for hair growth in androgenic alopecia.

The study investigated the effects of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) compared to conventional minoxidil treatment on androgenic alopecia (AGA) in 48 adult male albino rats. Results showed that stem cell therapy was more effective than minoxidil in treating AGA, as evidenced by changes in hair follicle dynamics, including a decrease in terminal hair number and an increase in vellus hair. Additionally, there were structural changes such as cavitations in hair and sheaths, collagen fiber deposition, and thinning of the arrector pili muscle. Overall, stem cell therapy demonstrated superior efficacy in promoting hair growth in AGA.

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