Anti-Aging Effects of Mesenchymal Stem Cell-Conditioned Medium in Mice Skin Model Induced by D-Galactose
July 2017
Studysummary In this study, subcutaneous injection of mesenchymal stem cell-conditioned medium promoted regeneration of mice skin aged by D-galactose, improving skin thickness, vascularization, and collagen density. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigated the anti-aging effects of mesenchymal stem cell-conditioned medium (MSC-CM) on a mice skin model induced by D-galactose. Thirty-nine mice were divided into four groups: control, D-galactose, saline-treated, and MSC-CM-treated. D-galactose was used to induce skin aging, and after induction, the mice received subcutaneous injections of either saline or MSC-CM. The results showed that MSC-CM improved skin structure and morphology, as evidenced by increased epidermal and dermal thickness, enhanced vascularization, hair follicle formation, and a high density of collagen fibers. This indicated that MSC-CM promoted the regeneration of aged skin in the mice model.
