Anti-Aging Effects of Mesenchymal Stem Cell-Conditioned Medium in Mice Skin Model Induced by D-Galactose

July 2017

IP Irma Padeta, Adp Armanda Dwi Prayugo, Wsn Widagdo Sri Nugroho, TB Teguh Budipitojo

mesenchymal stem cell-conditioned medium MSC-CM D-galactose epidermal thickness dermal thickness vascularization hair follicle formation collagen fibers

TLDR MSC-CM improved aged skin in mice.

The study investigated the anti-aging effects of mesenchymal stem cell-conditioned medium (MSC-CM) on a mice skin model induced by D-galactose. Thirty-nine mice were divided into four groups: control, D-galactose, saline-treated, and MSC-CM-treated. D-galactose was used to induce skin aging, and after induction, the mice received subcutaneous injections of either saline or MSC-CM. The results showed that MSC-CM improved skin structure and morphology, as evidenced by increased epidermal and dermal thickness, enhanced vascularization, hair follicle formation, and a high density of collagen fibers. This indicated that MSC-CM promoted the regeneration of aged skin in the mice model.

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