In Vivo Reprogramming of Wound-Resident Cells Generates Skin with Hair
March 2023
in “
bioRxiv (Cold Spring Harbor Laboratory)
”
Studysummary This study reports that transplantation and in vivo reprogramming using specific reprogrammed cell types can generate skin appendage-like structures in adult mice, suggesting potential therapeutic avenues for skin regeneration and disorders.
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The document reports a significant advancement in regenerative medicine, specifically in the regeneration of skin appendages like hair follicles and sweat glands, which are typically absent in scar tissue post-wound healing. The study demonstrates that by transplanting a combination of reprogrammed epithelial and mesenchymal cells, derived from adult mouse subcutaneous mesenchymal cells, into a wound, it is possible to generate skin with de novo (newly formed) appendages. Additionally, the development of a new adeno-associated virus (AAV) serotype enabled the in vivo reprogramming of wound-resident cells, leading to the creation of skin with hair in adult mice. This breakthrough offers promising therapeutic potential for treating skin appendage disorders, such as hair loss and dry skin, and could be applicable to the regeneration of other complex organs.
