In Vivo Reprogramming of Wound-Resident Cells Generates Skin with Hair

March 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Yuta Moriwaki, Qi Shen, H. Okada, Du Zening, Shogo Suga, Motoi Kato, Takao Numahata, Kexin Li, Koji Kanayama, Mutsumi Okazaki, Yusuke Hirabayashi, Juan Carlos Izpisúa Belmonte, Hironori Hojo, Masanori Kurita

hair follicles sweat glands scar tissue reprogrammed epithelial cells reprogrammed mesenchymal cells subcutaneous mesenchymal cells adeno-associated virus AAV in vivo reprogramming wound-resident cells skin appendage disorders hair loss dry skin reprogrammed cells skin disorders

TLDR Scientists can now create skin with hair by reprogramming cells in wounds.

The document reports a significant advancement in regenerative medicine, specifically in the regeneration of skin appendages like hair follicles and sweat glands, which are typically absent in scar tissue post-wound healing. The study demonstrates that by transplanting a combination of reprogrammed epithelial and mesenchymal cells, derived from adult mouse subcutaneous mesenchymal cells, into a wound, it is possible to generate skin with de novo (newly formed) appendages. Additionally, the development of a new adeno-associated virus (AAV) serotype enabled the in vivo reprogramming of wound-resident cells, leading to the creation of skin with hair in adult mice. This breakthrough offers promising therapeutic potential for treating skin appendage disorders, such as hair loss and dry skin, and could be applicable to the regeneration of other complex organs.

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March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Scientists can now create skin with hair by reprogramming cells in wounds.

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