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This study found that 15 clinical trials have been registered to investigate the use of mesenchymal stem cell-derived exosomes for treating skin and subcutaneous tissue diseases, particularly alopecia, with a growing global interest and most trials conducted in the United States and China.

This analysis found that mesenchymal stem cell-derived exosomes show potential as a safe and effective treatment for various skin and subcutaneous tissue diseases.

This controlled study found that patients with androgenetic alopecia treated with a combination of subcutaneous adipose-derived mesenchymal stem cells and oral minoxidil showed significantly better hair growth outcomes than those treated with oral minoxidil alone, with improvements ranging from 25-40% versus 5-10% over six months.

This study reports that mesenchymal stromal cell-derived extracellular vesicle injections led to complete hair regrowth in a patient with persistent chemotherapy-induced alopecia.

In this study, MSC-derived magnetic nanovesicles combined with a magnetic field increased skin retention and accelerated hair follicle growth in a mouse model of hair regeneration.