Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study suggests that a hair lotion containing methyl myristate loaded in cationic niosomes may effectively accelerate pigmentation in aged C57BL/6 mice compared to free methyl myristate.

This review discusses the cutaneous serotoninergic/melatoninergic system's potential role in skin function and resilience against environmental and internal stresses, but does not report new experimental findings.

In this study, Desmodesmus pannonicus water extract demonstrated significant antioxidative properties, inhibited melanin production, promoted wound healing in human keratinocyte cells, and showed potential for hair growth enhancement in human follicle dermal papilla cells, suggesting its promise for future dermatological applications.

This study found that α-MSH acts as a modulator of inflammatory and fibrogenic responses in human fibroblastic skin cells, indicating potential therapeutic options for fibrotic skin disorders and inflammatory diseases of the hair follicle.

This study found that dermatologic adverse events are common in children taking MEK inhibitors, with selumetinib patients experiencing less severe reactions and a lower risk of dosage adjustments. Age was noted as a factor in the likelihood of specific skin reactions.

In this case report, two Persian cats with Lynxacarus radovskyi fur mites and symptoms like mild alopecia and pruritus fully recovered after receiving selamectin spot-on treatment monthly for three months.

This article reviews the diverse regulatory roles of alpha-melanocyte-stimulating hormone in skin biology, highlighting its potential involvement in maintaining tissue homeostasis and protecting against inflammation-induced DNA damage but reports no new clinical findings.

This study found that LDE225, a novel Smo antagonist, shows potential as a topical treatment for basal cell carcinoma due to its high affinity binding and effective inhibition of tumor growth in preclinical models.

This article discusses the mechanisms behind chemotherapy-induced alopecia and the potential for permanent hair loss due to irreversible damage to hair follicle stem cells, but it reports no new clinical findings.

In this study, sarolaner administered orally proved effective in treating demodectic mange in a naturally infested cat in Brazil, as no mites were observed and skin condition improved after 21 days.

In this study, docetaxel combined with prednisone significantly extended survival by about 2.5 months in men with hormone-resistant metastatic prostate cancer compared to mitoxantrone plus prednisone, despite the potential for severe adverse effects.

This study found that DHEA significantly inhibited growth and induced autophagy in a mouse melanoma cell line, but showed only muffled inhibition and induced apoptosis in a human melanoma cell line.

This letter to the editor shares a case study of lentiginous melanoma that appears clinically malignant but histopathologically benign, involving the BRAFV600R mutation.

In this study, voglibose, commonly used for diabetes management, was found to reduce melanin synthesis and inhibit melanogenic signaling pathways in B16F10 melanoma cells, suggesting it could be repurposed for treating hyperpigmentation disorders with confirmed topical safety in human tests.

This review found that topical metformin shows potential as a treatment in dentistry for periodontitis and in dermatology for conditions like wound healing and acne, but results for melasma are inconsistent.

This study observed that topical flutamide may be as effective as hydroquinone for treating melasma, with a trend towards greater improvement and patient satisfaction, but recommends further research before clinical use.

This study found that C. japonicum flower extract significantly increased melanin content and cellular activity in human melanocytes and may improve follicular depigmentation and vitiligo through cAMP signaling.

This study found that N,N-dimethylglycine sodium salt promoted proliferation and migration of cultured human epidermal keratinocytes and had anti-inflammatory and antioxidant effects in vitro.

This study found that among the tested analogs, compound 4e was the most effective in inhibiting wax esters in vivo in the Golden Syrian hamster ear model.

This study found that hair regrowth in Pomeranians with hair cycle arrest treated with melatonin was not associated with a change in oestrogen receptor-α staining.

In this study, a 14-year-old girl developed Malassezia folliculitis and seborrheic dermatitis after starting trametinib, which improved with itraconazole treatment. The research underscores the importance of recognizing trametinib-related skin reactions and suggests managing them with antifungal therapy without necessarily discontinuing the medication.

In this study, two methotrexate-loaded liquid crystal formulations for topical application showed immunomodulatory effects and induced skin changes in mice with imiquimod-induced psoriasis.

Formestane is a preferred second-line treatment for advanced breast cancer in postmenopausal women because it's effective and has fewer side effects.

This study found that both Elental and 6-mercaptopurine were effective for maintaining remission in Crohn's disease, without a significant difference between them over 24 months.

In this animal study, agmatine exhibited a protective effect against seizures related to hormone fluctuations, with results suggesting that its anticonvulsant properties may involve interactions with central neurosteroids in female rats experiencing progesterone withdrawal.

Agomelatine might help stop hair loss caused by valproate.

This study found that azelaic acid entrapped in transethosomes exhibited enhanced antidermatophyte activity and improved treatment outcomes in guinea pig models of dermatophytosis compared to free azelaic acid.

This case report describes a 10-year-old terrier with pituitary-dependent hyperadrenocorticism successfully treated with mitotane.

In this study, PRP was found to show promise in treating melasma, offering consistent positive outcomes and satisfaction rates among patients, especially when combined with treatments like hydroquinone and tranexamic acid, though further research is needed to confirm long-term efficacy and safety.

This study suggests that melatonin enhances the growth properties of DP cells by activating the AKT/GSK3β/β-catenin signaling pathway through its receptors in a 3D culture system.