Nutritional Therapy Versus 6-Mercaptopurine as Maintenance Therapy in Patients with Crohn's Disease

    April 2012 in “ Digestive and Liver Disease
    Hiroyuki Hanai, Takayuki Iida, Ken Takeuchi, Hajime Arai, Osamu Arai, Jinrou Abe, Tatsuo Tanaka, Yasuhiko Maruyama, Kentaro Ikeya, Ken Sugimoto, Toshio Nakamura, Kouichi Nakamura, Fumitoshi Watanabe
    TLDR Elental is a good long-term treatment for Crohn's disease, similar to 6-mercaptopurine but with fewer side effects.
    The study compared the efficacy of an elemental diet (Elental) and 6-mercaptopurine as maintenance therapies for Crohn's disease over 24 months. Ninety-five patients with a Crohn's disease activity index ≤150 were divided into three groups: 6-mercaptopurine (n=30), Elental (n=32), and a control group (n=33), all receiving 5-aminosalicylic acid. The remission rates were 60% for 6-mercaptopurine, 46.9% for Elental, and 27.2% for the control group. Both 6-mercaptopurine and Elental were more effective than the control, with no significant difference between them. However, 6-mercaptopurine was associated with side effects, including liver injury and alopecia. The study concluded that Elental was as effective as 6-mercaptopurine for long-term maintenance therapy in Crohn's disease.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community 6 months of treatment and sudden shedding

      in Progress Pictures  8 upvotes 3 days ago
      A 28-year-old male experienced hair loss after COVID-19 and used Minoxidil with initial success, but later faced shedding again. He started Finasteride in February 2025, noticing improvements, but recent shedding has caused concern; his regimen includes Minoxidil, microneedling, ketoconazole shampoo, red light therapy, supplements, and a healthy lifestyle.

      community 6 months fin, min, dermastamp, RLT

      in Progress Pictures  142 upvotes 4 days ago
      The user has been using finasteride, minoxidil, a dermastamp, and red light therapy for six months with no visible improvement since the three-month mark. Other users noted improvement, particularly in the left temple area, and encouraged the user to continue.

      community 6-month Minoxidil progress update

      in Progress Pictures  14 upvotes 1 week ago
      A 29-year-old shared a 6-month update on using 5% topical minoxidil and occasional dermarolling, reporting improved hair density and a fuller crown. They are considering adding finasteride to their routine but are concerned about side effects.

      community 6 month 0.5 fin and nanoxidil update

      in Is this regrowth?  1564 upvotes 1 week ago
      The user reported positive hair regrowth results after six months of using 0.5 mg finasteride and nanoxidil, despite experiencing initial side effects like testicular pain and changes in libido. They noted that nanoxidil was chosen over minoxidil due to less scalp irritation.

    Related Research

    1 / 1 results