Nutritional Therapy Versus 6-Mercaptopurine as Maintenance Therapy in Patients with Crohn's Disease

    April 2012 in “ Digestive and Liver Disease
    Hiroyuki Hanai, Takayuki Iida, Ken Takeuchi, Hajime Arai, Osamu Arai, Jinrou Abe, Tatsuo Tanaka, Yasuhiko Maruyama, Kentaro Ikeya, Ken Sugimoto, Toshio Nakamura, Kouichi Nakamura, Fumitoshi Watanabe
    TLDR Elental is a good long-term treatment for Crohn's disease, similar to 6-mercaptopurine but with fewer side effects.
    The study compared the efficacy of an elemental diet (Elental) and 6-mercaptopurine as maintenance therapies for Crohn's disease over 24 months. Ninety-five patients with a Crohn's disease activity index ≤150 were divided into three groups: 6-mercaptopurine (n=30), Elental (n=32), and a control group (n=33), all receiving 5-aminosalicylic acid. The remission rates were 60% for 6-mercaptopurine, 46.9% for Elental, and 27.2% for the control group. Both 6-mercaptopurine and Elental were more effective than the control, with no significant difference between them. However, 6-mercaptopurine was associated with side effects, including liver injury and alopecia. The study concluded that Elental was as effective as 6-mercaptopurine for long-term maintenance therapy in Crohn's disease.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community 6 Months on Oral Fin + Oral Minoxidil

      in Progress Pictures  854 upvotes 2 weeks ago
      A user shared their 6-month progress using oral finasteride and oral minoxidil for hair loss, reporting significant improvements with minimal side effects, such as slight erectile dysfunction that resolved. Other users discussed their experiences, concerns about side effects, and the effectiveness of these treatments.

      community 6 weeks minoxidil… and spironolactone

      in Progress Pictures  35 upvotes 2 weeks ago
      Minoxidil and spironolactone are used for hair regrowth, with visible progress noted. Spironolactone is discussed as a treatment option, particularly in the context of transitioning, with concerns about its effects on men.

      community 6 months on min-fin medication

      in Progress Pictures  608 upvotes 2 weeks ago
      A 42-year-old user shared progress after 6 months using 1.25mg finasteride and 5mg oral minoxidil daily, with 5% topical minoxidil twice a day, improved nutrition, and weekly dermarolling. The user noticed some shedding and slower regrowth but remains disciplined, while others commented on the impressive results and potential side effects of high minoxidil doses.

      community 6 Month Transplant Update-Dr. Anuj, Medrootz (delhi)

      in Transplants  82 upvotes 1 month ago
      The user is very satisfied with their hair transplant results after six months, using finasteride, minoxidil, and ketoconazole shampoo. They praise Dr. Anuj and consider future touch-ups for a small untouched crown area.

      community 6 Month | Oral Finasteride Only 1mg Daily | Update (25m)

      in Finasteride/Dutasteride  223 upvotes 1 month ago
      A 25-year-old male experienced significant hair regrowth after taking 1mg of oral finasteride daily for six months, with no side effects reported. Previously, he had used finasteride combined with minoxidil but stopped all treatments for a year before resuming finasteride alone.

    Related Research

    1 / 1 results