Desmodesmus Pannonicus Water Extract Inhibits Melanin Synthesis and Promotes Wound Healing

November 2024 in “ Life ”

Kazuomi Sato, Yosuke Hiraga, Yuji Yamaguchi, Setsuko Sakaki, Hiroyuki Takenaka

Desmodesmus pannonicus melanin synthesis VEGF MMP CTGF HGF1 TGFβ1 hair growth antiandrogenic effects dermal papilla cells vascular endothelial growth factor matrix metalloproteinases connective tissue growth factor hepatocyte growth factor transforming growth factor beta 1

Studysummary In this study, Desmodesmus pannonicus water extract demonstrated significant antioxidative properties, inhibited melanin production, promoted wound healing in human keratinocyte cells, and showed potential for hair growth enhancement in human follicle dermal papilla cells, suggesting its promise for future dermatological applications. Our plain-language summary of this paper — not a Tressless recommendation.

The study examines the effects of Desmodesmus pannonicus water extract on skin health, highlighting its potential in treating hyperpigmentation, enhancing wound healing, and promoting hair growth. The extract demonstrated strong antioxidative properties, inhibited melanin production in B16F1 melanoma cells by suppressing tyrosinase expression, and promoted wound healing in HaCaT cells by enhancing cell migration and upregulating VEGF and MMP mRNA levels. It also influenced hair growth-related genes in human follicle dermal papilla cells, suggesting potential hair growth promotion and antiandrogenic effects. The extract showed no toxicity and exhibited strong antioxidant activity, making it a promising candidate for dermatological applications.

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