Efficacy and Safety of Platelet-Rich Plasma in Melasma: A Systematic Review

This systematic review evaluated the efficacy and safety of platelet-rich plasma (PRP) in treating melasma, including 8 studies primarily involving female participants. The findings consistently showed positive outcomes, with PRP used alone or in combination with treatments like hydroquinone and tranexamic acid, leading to improved satisfaction rates and reductions in the melasma area and severity index (MASI) scores. While combined treatments often enhanced results, they did not isolate PRP's specific effects. Overall, PRP appears to be a promising therapeutic option for melasma, but further extensive trials are needed to confirm its long-term efficacy and safety.