Studysummary In this review, platelet concentrates were found to show comparable efficacy to steroids and immunosuppressive drugs in treating oral lichen planus, with some studies reporting more benefits and others noting more severe adverse reactions with platelet treatments. Our plain-language summary of this paper — not a Tressless recommendation.
This comprehensive review evaluates the use of platelet-rich concentrates (PRCs) in treating oral lichen planus (OLP), comparing them to traditional treatments like corticosteroids. It includes 14 studies on injectable platelet-rich fibrin (i-PRF), injectable platelet-rich plasma (i-PRP), and PRP gel. The findings suggest that PRCs have comparable efficacy to traditional treatments, with some studies showing more beneficial effects, particularly in steroid-resistant cases. However, one study reported more severe adverse reactions in the PRC group. Despite these mixed results, PRCs are considered a promising alternative due to their anti-inflammatory properties, though further research is needed to confirm their efficacy and safety.
4 citations
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October 2024 in “BMC Oral Health” This review suggests that PRF may be a promising alternative treatment for oral mucosal lesions, but further research is needed to confirm its long-term effectiveness and standardize preparation protocols.
June 2024 in “Stem cell research & therapy” This systematic review examined 64 randomized controlled clinical trials on regenerative medicine for specific dermatologic disorders, reporting up to 68.4% improvement in androgenetic alopecia and up to 71% improvement in vitiligo among 2888 patients.
1 citations
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December 2023 in “Life” This article discusses the potential role of telocytes in skin regeneration and the need to understand their interaction with platelet-rich plasma, reporting no new experimental results.
1 citations
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November 2022 in “Journal of Dermatological Treatment” This review discusses the use of platelet-rich plasma for various dermatologic conditions but reports inconsistent evidence and a lack of standardized protocols; patients often report high satisfaction despite mixed clinical outcomes.
5 citations
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October 2021 in “Dermatologic Surgery” This review found that platelet-rich plasma shows potential in improving melasma, though its overall benefit varies across different treatment methods and may not enhance results when combined with certain other treatments.
25 citations
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September 2019 in “PubMed” This review discusses the therapeutic potential of platelet-rich plasma in dermatology and highlights the need for standardized treatment protocols, but reports no new clinical results.
