The First Clinical Experience on Efficacy of Topical Flutamide on Melasma Compared with Topical Hydroquinone: A Randomized Clinical Trial
August 2015
in “
Drug Design Development and Therapy
”
TLDR Topical flutamide works as well as hydroquinone for melasma but needs more safety checks.
In a randomized clinical trial conducted in 2015, topical flutamide was found to be as effective as topical hydroquinone in treating melasma, as measured by mexameter assessment. However, flutamide showed a better trend in MASI improvement and higher patient satisfaction compared to hydroquinone. Despite these promising results, the study's authors advised against recommending flutamide for clinical use until further studies confirmed its efficacy and safety.
