The First Clinical Experience on Efficacy of Topical Flutamide on Melasma Compared with Topical Hydroquinone: A Randomized Clinical Trial

    August 2015 in “ Drug Design Development and Therapy ”
    Homayoun Sadeghi‐Bazargani, Hassan Edalatkhah
    TLDR Topical flutamide works as well as hydroquinone for melasma but needs more safety checks.
    This study compared 1% topical flutamide cream to 4% hydroquinone cream in treating melasma in a randomized clinical trial with 74 women. Flutamide demonstrated higher efficacy in terms of patient satisfaction and Melasma Area and Severity Index (MASI) scores, and was relatively safe compared to hydroquinone. The study suggested flutamide as a promising alternative for melasma treatment, highlighting the potential hormonal role in melasma's pathogenesis. However, the study was limited by its short duration of 120 days and small sample size, indicating the need for larger and longer studies to confirm flutamide's efficacy and safety.
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