Differential Effects of Dehydroepiandrosterone (DHEA) Between Mouse and Human Melanoma Cell Lines
January 2016
TLDR DHEA inhibits growth in both mouse and human melanoma cells but works differently in each.
The study investigated the effects of dehydroepiandrosterone (DHEA) on melanoma, comparing mouse (B16F10) and human (BLM) melanoma cell lines. DHEA was found to inhibit growth and induce autophagy in mouse cells, while in human cells, it caused a less pronounced inhibition and induced apoptosis. The effects were mediated through the androgen receptor in both cell lines. Additionally, combining DHEA with progesterone enhanced growth inhibition in mouse cells but not in human cells. These findings highlighted the differential effects of DHEA between species, aligning with previous research.
