Development, Optimization, And In Vitro/In Vivo Evaluation Of Azelaic Acid Transethosomal Gel For Antidermatophyte Activity

    April 2023 in “ Antibiotics ”
    Ali M. Nasr, Noha M. Badawi, Yasmine H. Tartor, Nader M. Sobhy, Shady A. Swidan
    TLDR Azelaic acid in a special gel is more effective against skin fungi than regular azelaic acid.
    The study developed and optimized azelaic acid transethosomal gels (AzA-TEs) to enhance antidermatophyte activity and improve skin delivery. The optimized gel showed a mean particle size of 219.8 nm, a zeta potential of -36.5 mV, and an entrapment efficiency of 81.9%. In vitro tests revealed significantly greater antidermatophyte activity of AzA-TEs compared to free AzA, with low minimum inhibitory concentrations (MIC90) for T. rubrum, T. mentagrophytes, and M. canis. In vivo studies on guinea pigs demonstrated an 83% mycological cure rate with AzA-TEs, outperforming itraconazole and free AzA. The study concluded that AzA-TEs are promising carriers for enhancing azelaic acid's penetration and therapeutic efficacy against dermatophytosis.
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