Development, Optimization, And In Vitro/In Vivo Evaluation Of Azelaic Acid Transethosomal Gel For Antidermatophyte Activity
April 2023
in “
Antibiotics
”
New to Azelaic Acid? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that azelaic acid entrapped in transethosomes exhibited enhanced antidermatophyte activity and improved treatment outcomes in guinea pig models of dermatophytosis compared to free azelaic acid. Our plain-language summary of this paper — not a Tressless recommendation.
The study developed and optimized azelaic acid transethosomal gels (AzA-TEs) to enhance antidermatophyte activity and improve skin delivery. The optimized gel showed a mean particle size of 219.8 nm, a zeta potential of -36.5 mV, and an entrapment efficiency of 81.9%. In vitro tests revealed significantly greater antidermatophyte activity of AzA-TEs compared to free AzA, with low minimum inhibitory concentrations (MIC90) for T. rubrum, T. mentagrophytes, and M. canis. In vivo studies on guinea pigs demonstrated an 83% mycological cure rate with AzA-TEs, outperforming itraconazole and free AzA. The study concluded that AzA-TEs are promising carriers for enhancing azelaic acid's penetration and therapeutic efficacy against dermatophytosis.
