Evaluation of Methotrexate-Loaded Surfactants, Ceramides, and Cholesterol-Based Lamellar Phases as a Topical Treatment for Psoriasis

February 2022 in “ Journal of Pharmacy and Pharmacology ”

Cintia Oliveira Alves, Rômulo Dias Novaes, Maria Tereza Carneiro Paschoal Bernardes, Reggiani Vilela Gonçalves, Laíla Pereira da Silva, Sandra Barbosa Neder Agostini, Gislaine Ribeiro Pereira, Flávia Chiva Carvalho

methotrexate ceramides cholesterol stearic acid IL-1 IFN-γ TNF-α prostaglandin E2 keratinization epidermis thickness inflammatory infiltrate

TLDR Methotrexate-loaded formulations showed promise for psoriasis treatment but need careful evaluation.

The study evaluated methotrexate-loaded surfactants, ceramides, and cholesterol-based lamellar phases as a topical treatment for psoriasis using a mouse model. The formulations, C1CH and C1CHCE, showed significant immunomodulatory effects, such as increased epidermal thickness and inflammatory cytokine levels, but did not outperform dexamethasone in reducing psoriasiform dermatitis symptoms. The study concluded that while these formulations could potentially enhance methotrexate delivery, they induced inflammation and worsened skin conditions, highlighting the need for careful evaluation of liquid crystals as topical drug delivery systems for psoriasis. The number of participants was not specified, limiting the assessment of the study's strength.

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research Evaluation of Methotrexate-Loaded Surfactants, Ceramides, and Cholesterol-Based Lamellar Phases as a Topical Treatment for Psoriasis

2 citations , February 2022 in “Journal of Pharmacy and Pharmacology”

Methotrexate-loaded formulations showed promise for psoriasis treatment but need careful evaluation.