Pustular Eruption in a Patient Treated With Trametinib
December 2025
in “
Pediatric Dermatology
”
Studysummary In this study, a 14-year-old girl developed Malassezia folliculitis and seborrheic dermatitis after starting trametinib, which improved with itraconazole treatment. The research underscores the importance of recognizing trametinib-related skin reactions and suggests managing them with antifungal therapy without necessarily discontinuing the medication.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
A 14-year-old girl developed skin lesions after starting trametinib for a hypothalamic-chiasmatic pilomyxoid astrocytoma. Examination revealed pustules and erythema, diagnosed as Malassezia folliculitis and seborrheic dermatitis. Trametinib was discontinued, and treatment with oral itraconazole and topical creams led to improvement. Malassezia folliculitis is often misdiagnosed as acne, but dermoscopy can aid in its identification. While trametinib can cause various dermatologic toxicities, including acneiform dermatitis, most can be managed without stopping the drug. Dermatologists should recognize these reactions to avoid unnecessary treatment interruptions.
