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    Glossary Macrophage Migration Inhibitory Factor

    protein that regulates immune responses and inflammation

    Macrophage Migration Inhibitory Factor (MIF) is a protein that plays a crucial role in the immune system by regulating inflammation and immune responses. It inhibits the movement of macrophages, which are cells that engulf and digest pathogens and cellular debris, thereby helping to control the body's inflammatory response. MIF is also involved in various diseases, including autoimmune disorders and cancer, making it a significant target for medical research.

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    1. Increased Macrophage Migration Inhibitory Factor (MIF) in the Sera of Patients with Extensive Alopecia Areata 2002 · 14 citations
    2. Serum Level of Macrophage Migration Inhibitory Factor (MIF) in Egyptians With Alopecia Areata and Its Relation to the Clinical Severity of the Disease Journal of Clinical Laboratory Analysis · 2014 · 13 citations
    3. Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth Cells · 2020 · 19 citations
    4. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007 · 253 citations
    5. 259 Immunohistochemical insight into the association between the collapse of immune privilege in the sweat gland and syringotropic immune cell infiltrates in collagen diseases Journal of Investigative Dermatology · 2017
    6. Wound Healing: A Cellular Perspective Physiological Reviews · 2018 · 1160 citations
    7. Molecular mediators involved in skin healing: a narrative review F1000Research · 2022 · 3 citations
    8. 15-Hydroxyprostaglandin Dehydrogenase Inhibitor Restores Endothelial Function Under Dihydrotestosterone-Induced Stress in Human Dermal Microvascular Endothelial Cells Molecules · 2025
    9. Pathomechanisms of immune-mediated alopecia International Immunology · 2019 · 45 citations
    10. Adipose stem cells from type 2 diabetic mice exhibit therapeutic potential in wound healing Stem Cell Research & Therapy · 2020 · 21 citations
    11. GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states PLOS Genetics · 2017 · 38 citations
    12. Role of the SOX family in cancer immune evasion: Emerging player and promising therapeutic opportunities Medicine · 2025 · 1 citations
    13. Mechanical stretch induces hair regeneration through the alternative activation of macrophages Nature Communications · 2019 · 163 citations
    14. 1359 Hair growth is induced by blockade of macrophage-derived oncostatin M and downstream JAK-STAT5 signaling in hair follicle stem cells Journal of Investigative Dermatology · 2018
    15. Analysis of hidradenitis suppurativa–linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages Human Molecular Genetics · 2018 · 25 citations
    16. Fibromodulin-Deficiency Alters Temporospatial Expression Patterns of Transforming Growth Factor-β Ligands and Receptors during Adult Mouse Skin Wound Healing PLOS ONE · 2014 · 32 citations
    17. Tsukushi is involved in the wound healing by regulating the expression of cytokines and growth factors Journal of Cell Communication and Signaling · 2014 · 21 citations
    18. Neutralization of IL-8 Prevents the Induction of Dermatologic Adverse Events Associated with the Inhibition of Epidermal Growth Factor Receptor PLoS ONE · 2012 · 32 citations
    19. Is COVID-19 a risk factor for progression of benign prostatic hyperplasia and exacerbation of its related symptoms?: a systematic review Prostate Cancer and Prostatic Diseases · 2021 · 21 citations
    20. Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia PLOS ONE · 2012 · 22 citations
    21. Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus Scientific Reports · 2020 · 13 citations
    22. 258 11β-hydroxysteroid dehydrogenase type 1 inhibition attenuates the adverse effects of glucocorticoids on dermal papilla cells Journal of Investigative Dermatology · 2017 · 1 citations
    23. Epigenetic orchestration of RNA m<sup>6</sup>A methylation in wound healing and post-wound events International Journal of Biological Sciences · 2025 · 3 citations
    24. The control of hair growth: An overview Journal of Investigative Dermatology · 1993 · 62 citations
    25. Immune cell regulation of the hair cycle Experimental Dermatology · 2020 · 27 citations
    26. Function of KLF4 in Stem Cell Biology InTech eBooks · 2013 · 5 citations
    27. Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women BMC women's health · 2023 · 2 citations
    28. Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair Nature Communications · 2016 · 86 citations
    29. Mechanism of action of herbs and their active constituents used in hair loss treatment Fitoterapia · 2016 · 47 citations
    30. 1362 The role of Fgf20 in establishing the hair follicle dermal condensate Journal of Investigative Dermatology · 2018