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This review examines the role of P-cadherin in skin and hair biology, emphasizing its importance in human hair growth, cycling, and pigmentation, and reports no new research findings.

This review discusses various Wnt pathway modulators developed between 2014 and 2020, highlighting their potential as treatments for diseases like cancer and osteoarthritis, but reports no new clinical results.

This article reviews the role of exosomes in promoting axonal regeneration and discusses recent findings on how exosome-borne molecules might influence the PTEN-mTOR pathway in injured neurons; it reports no new experimental results.

The study found that a specific signaling pathway helps skin wounds heal faster but may lead to larger scars.

This study suggests that the long noncoding RNA H19 helps dermal papilla cells maintain their hair follicle-inducing ability by activating the Wnt signaling pathway, potentially offering a therapeutic target for androgenetic alopecia.

This study demonstrated that troxerutin may protect human dermal papilla cells from H2O2-induced damage and suggests potential in treating alopecia by inhibiting ROS-mediated cellular damage.

This article discusses the use of forensic DNA phenotyping to infer physical characteristics from biological samples without a reference sample, aiding investigations but raising ethical and legal concerns.

This study found that Wnt5a regulates hair follicle differentiation in mice by mediating epithelial-mesenchymal interactions and influencing dermal papilla cell activities.

This study found that combining microneedling with 5% minoxidil improved hair growth in Chinese men with androgenetic alopecia, possibly through activating the Wnt/β-catenin signaling pathway.

Drugmakers are optimistic about targeting the Wnt pathway for new treatments despite past challenges.

This study found that DECORIN promotes the proliferation and migration of outer root sheath keratinocytes in vitro and maintains the hair anagen phase in mice.

This review explores the regenerative potential of hair follicles and their role in complete skin regeneration, emphasizing the influence of mechanical factors and niche signaling pathways on hair growth and loss.

This study found elevated tissue levels of DKK-1 in patients with both androgenetic alopecia and alopecia areata compared to controls, suggesting DKK-1 as a potential therapeutic target for these conditions.

This study suggests that CTHRC1, a protein expressed in cardiac fibroblasts, may improve wound repair and prevent cardiac rupture after myocardial infarction by activating a specific signaling pathway.

This review discusses historical and recent advances in understanding the embryonic organizer's role in patterning during development, including molecular pathways and future research challenges, but reports no new experimental data.

In this study, treatment with recombinant DKK2 was shown to significantly stimulate hair progenitor cell growth and enhance hair shaft elongation in ex vivo human hair follicle cultures by activating the Wnt/ẞ-catenin signaling pathway, suggesting a potential role for DKK2 in promoting hair growth.

In this study, re-activating SOX9 in adult epidermal stem cells led to a fate switch towards hair follicle stem cell identity, with altered chromatin dynamics and oncogenic activation, contributing insights into developmental processes and cancer pathways.

This study identified key genes and pathways involved in the seasonal hair cycle regulation of yak, uncovering molecular mechanisms that may aid in understanding their adaptation to alpine environments.

This study reported that narrowband UVB treatment significantly increased WNT7B, WNT10B, and TCF7L2 gene expression in lesional skin of psoriasis patients, suggesting these genes may play a role in psoriasis pathogenesis.

This article reviews the role of KLF4, a transcription factor, in various cellular processes and its dual function as a tumor suppressor or oncogene depending on the context, but presents no new experimental results.

This study suggests that EDA-A2 induces apoptosis in hair follicles by increasing DKK-1 expression, implicating EDA2R signaling as a potential therapeutic target for androgenetic alopecia.

This study compiled an archive of 684 genes associated with monogenic hair disorders, identifying previously unrecognized components of Hippo signaling and proposing a new biologically-grounded disease taxonomy.

This study presents a detailed overview of lymphatic vessel development and highlights the role of abnormal lymphangiogenesis in various diseases, suggesting that targeting lymphangiogenic factors may improve treatment strategies.

This study identified key genes and signaling pathways involved in cashmere goat hair follicle growth cycles, influenced by melatonin implantation, suggesting a basis for further research on melatonin's regulatory mechanism.

This study reported successful recovery of biologically active recombinant murine Wnt3a without detergent, suggesting usefulness for structure-activity studies avoiding detergent-related issues.

This review suggests that the gut microbiome and metabolome may play a significant role in alopecia areata and emphasizes the potential of targeting these factors for improved prevention, diagnosis, and treatment strategies for this skin condition.

This study found that mesenchymal cells in mouse and chicken embryonic skin undergo a process of migration driven by tissue tension and WNT secretion, influencing their dispersal and integration into dermal condensates.

In this review, researchers explored the multifaceted role of NF-κB signaling in various biological processes and diseases, including its interactions with other pathways, and discussed possible therapeutic approaches targeting this pathway for treating conditions like cancer, autoimmune disorders, and COVID-19.

This review outlines recent advancements in understanding how micro-RNAs (miRNAs) influence hair regeneration, highlighting their role in stimulating hair growth and potential therapeutic approaches, while also addressing the challenges of clinical translation due to miRNAs' complex roles and delivery issues.

This study found that CD200-negative human hair follicle bulge cells have a higher hair-regenerative capability compared to CD200-positive cells, suggesting that reduced CD200 expression may enhance hair regeneration, providing insights for improving bulge cell-based hair restoration techniques.