Regenerative Potential of CD200- Subpopulations of Hair Follicle Bulge

    April 2026 in “ Frontiers in Cell and Developmental Biology ”
    Ting Sun, Sayuri Hamano, Jing Chen … Junji Fukuda
    Studysummary This study found that CD200-negative human hair follicle bulge cells have a higher hair-regenerative capability compared to CD200-positive cells, suggesting that reduced CD200 expression may enhance hair regeneration, providing insights for improving bulge cell-based hair restoration techniques.
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    Research cited in this study 10

    1. LGR5 Is a Conserved Marker of Hair Follicle Stem Cells in Multiple Species and Is Present Early and Throughout Follicle Morphogenesis Scientific Reports · 2022
    2. Electrical Stimulation to Human Dermal Papilla Cells for Hair Regenerative Medicine Journal of Bioscience and Bioengineering · 2022
    3. Isolation, Cultivation, and Morphological Characteristics of Hair Follicle Adult Stem Cells in the Bulge Region in Mouse and Human Microscopy research · 2020
    4. Hardwiring Stem Cell Communication Through Tissue Structure Cell · 2016
    5. Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress During Hair Cycling PloS one · 2015
    6. Stem Cell Heterogeneity and Plasticity in Epithelia Cell Stem Cell · 2015
    7. Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine Tissue Engineering Part B-reviews · 2012
    8. Differential Expression of Stem Cell Markers in Human Follicular Bulge and Interfollicular Epidermal Compartments Histochemistry and Cell Biology · 2010
    9. Epidermal Stem Cells: Practical Perspectives and Potential Uses British Journal of Dermatology · 2009
    10. Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation Developmental Biology · 2008