research Transcriptomic Profiling in Silurana Tropicalis Testes Exposed to Finasteride
Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.
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5 / 1000+ results research Comprehensive Single-Cell Transcriptomic Profiling of the Scalp from Patients with Moderate-to-Severe Alopecia Areata
research 682 Identification of novel potential therapeutic targets by comparative transcriptomic profiling of physiological and pathological skin wounds ex vivo
This study investigates the molecular mechanisms of wound healing by comparing transcriptomic profiles of acute and chronic wounds in cultured human skin. Key findings include differential expression of genes like FGF7, MMP10, and osteopontin (SPP1) between acute and chronic wounds. Notably, MMP10-neutralizing antibody increased wound healing in acute wounds, while recombinant FGF7 alone had no effect. However, their combined application enhanced re-epithelization in both wound types. Additionally, the osteopontin-derived peptide FOL005 significantly promoted skin re-epithelization under both conditions. The study suggests that combined therapeutic targeting, including the use of FOL005, may improve treatment of unresolved wounds.
research Proteomics and Transcriptomics Profiling Define Molecular Subtypes of Advanced Cutaneous T Cell Lymphoma and Prognostic Biomarkers
Three molecular subtypes of advanced skin T-cell lymphoma were identified, with potential biomarkers for predicting treatment response and disease progression.
research Transcriptomic Analysis to Identify Protective Dermal Papilla Signature in Occipital Scalp
The research found genes that may protect certain scalp cells from hair loss.
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4 / 4 resultscommunity Results of Procyanidin B2 in clinical studies
Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.
community Journey against alopecia - Finasteride 3 month
A 26-year-old man from France started experiencing hair loss in September 2020 and began using finasteride in June 2021, reporting some improvement after three months without side effects. He plans to continue finasteride for a year before considering additional treatments like minoxidil or dermarolling.
community Bee venom better than minoxidil?
Bee venom at 0.001% concentration was more effective than 2% minoxidil in promoting hair growth in mice, possibly due to increased growth factors and reduced inflammation. Caution is advised due to potential allergic reactions and the reliance on animal data.
community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System
PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.