Isolation, Cultivation, and Morphological Characteristics of Hair Follicle Adult Stem Cells in the Bulge Region in Mouse and Human

    January 2020 in “ Microscopy research ”
    Bélgica J. Molina, Héctor J. Finol
    TLDR Researchers successfully grew hair follicle stem cells from mice and humans, which could be useful for tissue engineering and regenerative medicine.
    The study successfully isolated and cultivated hair follicle adult stem cells (HFSCs) from the bulge region in both mice and humans, using specific markers (CD34 in mice and CD200 in humans) to identify them. Mouse HFSCs proliferated faster and formed more colonies compared to human HFSCs. The cells maintained their stem cell characteristics and high proliferative capacity over extended periods, showing potential for differentiation into various cell types. This research provided a foundation for future therapeutic applications in treating conditions like alopecia, highlighting the potential of HFSCs for regenerative medicine and hair loss treatments.
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