Isolation, Cultivation, and Morphological Characteristics of Hair Follicle Adult Stem Cells in the Bulge Region in Mouse and Human

January 2020 in “ Microscopy research ”

Bélgica J. Molina, Héctor J. Finol

hair follicle adult stem cells HFSCs bulge region CD34 CD200 alopecia regenerative medicine hair loss treatments stem cells hair loss

TLDR Researchers successfully grew hair follicle stem cells from mice and humans, which could be useful for tissue engineering and regenerative medicine.

The study successfully isolated and cultivated hair follicle adult stem cells (HFSCs) from the bulge region in both mice and humans, using specific markers (CD34 in mice and CD200 in humans) to identify them. Mouse HFSCs proliferated faster and formed more colonies compared to human HFSCs. The cells maintained their stem cell characteristics and high proliferative capacity over extended periods, showing potential for differentiation into various cell types. This research provided a foundation for future therapeutic applications in treating conditions like alopecia, highlighting the potential of HFSCs for regenerative medicine and hair loss treatments.

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research Identification of Bulge Stem Cells in Mouse and Human Hair Follicles

research Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells

research Multipotent Nestin-Expressing Stem Cells Capable of Forming Neurons Are Located in the Upper, Middle, and Lower Part of the Vibrissa Hair Follicle

research hMSCs possess the potential to differentiate into DP cellsin vivoandin vitro

research Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo

research Clonal Multipotency and Effect of Long-Term In Vitro Expansion on Differentiation Potential of Human Hair Follicle Derived Mesenchymal Stem Cells

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research Review of Hair Follicle Dermal Cells

research Nonviral In Situ Green Fluorescent Protein Labeling and Culture of Primary, Adult Human Hair Follicle Epithelial Progenitor Cells

research Epidermal Stem Cells: Practical Perspectives and Potential Uses

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research Bulge Cells of Human Hair Follicles: Segregation, Cultivation, and Properties

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

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research Molecular Principles of Hair Follicle Induction and Morphogenesis

research Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge

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