Dickkopf-Related Protein 2 Promotes Hair Growth by Upregulating the Wnt/β-Catenin Signaling Pathway in Human Dermal Papilla Cells

January 2024 in “ Annals of Dermatology ”

Seon Bok Lee, Jae Won Lee, H Lee, Kyung-Ju Lee, Hye-Won Hwang, Hyun‐Tae Shin, Ji Won Byun, Jeonghyun Shin, Gwang Seong Choi

TLDR Dickkopf-related Protein 2 can help hair grow by activating a specific cell pathway.

The study demonstrates that recombinant human Dickkopf-related Protein 2 (rhDKK2) can promote hair growth by enhancing the proliferation of human dermal papilla cells (DPCs). This effect is achieved through the activation of the Wnt/β-catenin signaling pathway, suggesting a potential therapeutic target for hair loss treatments.

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Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

207 citations , March 2012 in “Development”

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

171 citations , July 2007 in “Journal of Investigative Dermatology”

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

research Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion

176 citations , September 2006 in “Stem Cells”

BMP signaling prevents hair growth by stopping stem cell activation.

Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells

Dickkopf-Related Protein 2 Promotes Hair Growth by Upregulating the Wnt/β-Catenin Signaling Pathway in Human Dermal Papilla Cells

Research cited in this study

research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

research Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion

research Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

research Simple and Rapid Method to Isolate and Culture Follicular Papillae from Human Scalp Hair Follicles

research Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin

research Expression of the Bcl-2 Proto-Oncogene in the Cycling Adult Mouse Hair Follicle