In this study, researchers developed a mucoadhesive hydrogel ovule containing retinyl palmitate and curcumin for intravaginal use, showing controlled drug release, selectivity against cancerous HeLa cells, and non-toxicity to healthy cells, which may offer a potential treatment for cervical cancer.
May 2023 in “Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy” This study developed a synchronized fluorescence spectroscopic approach to quantify finasteride and tadalafil in various forms, achieving high accuracy with %recoveries of about 99.62% and 100.19% respectively, and demonstrated superior environmental friendliness compared to previous methods.
December 2023 in “Animals” In this study, researchers analyzed miRNA and gene expression in the hair follicles of FMD during different hair cycle stages, identifying differential expression patterns and key pathways involved in hair follicle development and growth.
18 citations
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April 1989 in “Clinics in Dermatology” This study found that using an argon gas-based system for intralesional cryotherapy significantly reduced keloid scar volume, improved scar quality, and resulted in low recurrence rates after 12 months.
3 citations
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May 2022 in “Clinical endocrinology” This study found that measuring certain steroids in hair can help diagnose and monitor congenital adrenal hyperplasia in Indonesian patients, offering a simple noninvasive method for developing countries.
March 2023 in “Agroland: The Agricultural Sciences Journal/Agroland : The Agricultural Sciences Journal” This review discusses the potential cosmeceutical benefits of Pontianak Aloe Vera, highlighting its use in products for skin and hair care, and reports no new results.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This guide explores the fundamental science and practical applications of nanocrystal technologies to enhance the bioavailability of poorly water-soluble drugs, detailing synthesis methods, stability solutions, and drug delivery innovations like hydrogel composites and microneedle platforms.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This comprehensive guide from nanotechsci.com explores how nanocrystal technology enhances the bioavailability of poorly water-soluble pharmaceuticals, detailing the science behind crystallization and practical synthesis techniques, and discussing their advanced drug delivery applications across various routes.
January 2025 in “Journal of Medicinal Food” This abstract mentions that while synthetic drugs like minoxidil and finasteride for androgenic alopecia have side effects, the characteristics of popular natural alternatives, such as soybean, remain largely unreported, despite consumer preference for these products.
July 2024 in “ACS Biomaterials Science & Engineering” In this study, researchers used a 3D in vitro organ culture system to show that rifampicin-loaded lipid nanocapsules can penetrate hair follicles more effectively than free rifampicin, highlighting the potential advantage of nanocarrier-based antibiotic treatments for follicular infections.
4 citations
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June 2013 in “PubMed” This study found that minoxidil in Espumil Foam Base remains stable for at least 90 days when stored at room temperature and protected from light.
3 citations
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August 2022 in “Pharmaceuticals” This study observed that a self-emulsifying drug delivery system for finasteride significantly enhanced bioavailability in rats compared to commercial tablets, but the formulation was found to be thermodynamically unstable.
1 citations
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May 2024 in “Applied Sciences” This review analyzed current studies on metabolite production from the medicinal fungus Cordyceps militaris, focusing on its fermentation modes and biological functions, and emphasizes the need for modern fermentation processes to enhance industrial production.
August 2018 in “Jundishapur journal of natural pharmaceutical products” Transfollicular drug delivery can improve medication absorption through hair follicles.
March 2026 in “Journal of medical & health sciences review.” In this study, both 5% minoxidil foam and 5% minoxidil liquid solution effectively improved hair diameter and density in male patients with androgenetic alopecia over 12 weeks, with the foam formulation showing a slight advantage in patient satisfaction and hair density gain.
211 citations
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March 2011 in “Journal of Lipid Research” This study reports a novel LC/MS method that separates and analyzes all known ceramide subclasses in human stratum corneum, identifying a new subclass, CER [EOdS], with minimal sample preparation.
127 citations
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June 2006 in “International Journal of Pharmaceutics” This research found that liquid-state liposomes and niosomes may enhance finasteride delivery to pilosebaceous units in hamsters more effectively than gel-state vesicles or hydroalcoholic solution.
73 citations
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January 2002 in “Journal of Investigative Dermatology” In this study, researchers found that connexin 43-negative cells in the basal layer of the epidermis could serve as markers for keratinocyte stem cells, aiding their identification and separation.
15 citations
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August 2020 in “Analytical chemistry” This study observed that lipids in human hair accumulate in specific areas and do not significantly impact water permeability, highlighting the utility of AFMIR for studying complex biomaterials.
12 citations
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January 2020 in “Analyst” This study found that untargeted hair metabolomics analysis detected significantly altered endogenous biomolecules, potentially serving as biomarkers for identifying oxidative cosmetic hair treatments like bleaching.
9 citations
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November 2022 in “International Journal of Molecular Sciences” This study found that LC-MS/MS assays provided more reliable and precise steroid measurements in human serum compared to traditional immunoassays, particularly at lower concentrations.
In this study, imaging techniques showed that nanostructured lipid carrier formulations distributed ascorbic acid more effectively across skin layers compared to conventional cream formulations, suggesting a better method for skin permeation.
November 2025 in “Molecules” This review examines recent advancements in green and emerging microextraction techniques, such as SPME and DLLME, for more sustainable hormone detection in biological samples, emphasizing environmentally friendly solvents and bioanalytical applications.
September 2023 in “Biomedicines” In this study, researchers found that subjects with clinical alopecia had significantly higher levels of squalene in their hair bulbs compared to controls, suggesting squalene as a potential metabolic and pathogenic marker for certain alopecia conditions.
19 citations
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December 2002 in “Journal of Liquid Chromatography & Related Technologies” This study developed and validated a high-performance liquid chromatographic method for identifying finasteride and its degradation products, showing excellent resolution and sensitivity under various decomposition conditions.
8 citations
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November 2019 in “International Journal of Pharmaceutics” This work explores using a liquid crystalline phase to stabilize benzoyl peroxide nanosuspensions, suggesting a promising method to potentially reduce the side effects of acne treatments.
In this study, researchers assessed the physical-chemical and microbiological stability of various pharmaceutical ingredients in the vehicle TrichoSolTM, finding differing beyond-use dates for the compounds, such as 180 days for cetirizine hydrochloride, but only 90 days for progesterone at higher concentrations.
April 2022 in “Molecules” This study identified two potent 5α-reductase inhibitors from Tectona grandis leaves, and suggests that ethanol is a preferable solvent for extracting these compounds, which are potential ingredients for hair loss treatments.
23 citations
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June 2015 in “Journal of Tissue Engineering and Regenerative Medicine” This study demonstrated that a 3D air–liquid culture system using Wnt-CM-treated cells can induce hair regeneration in nude mice and may facilitate large-scale preparation for hair loss treatment.
5 citations
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January 1994 in “Skin Pharmacology and Physiology” This study found that minoxidil forms a reservoir in the skin, allowing sustained drug delivery even after cleansing, while propylene glycol does not.