Stability of Minoxidil in Espumil Foam Base

May 2013 in “ PubMed ”

Christine M Geiger, Bridget Sorenson, Paul A Whaley

minoxidil Espumil Foam Base hydroalcoholic compounding vehicle contact dermatitis high-performance liquid chromatography Rogaine HPLC

TLDR Minoxidil in Espumil foam stays stable for at least 90 days at room temperature.

The study aimed to determine the stability of minoxidil in Espumil Foam Base, a hydroalcoholic compounding vehicle designed to minimize greasiness, itching, burning, and contact dermatitis. Minoxidil was compounded into a 50-mg/mL solution and stored in a plastic foam-activating bottle at room temperature. Stability was assessed over 90 days using a validated high-performance liquid chromatography method. The results indicated that minoxidil remained stable for at least 90 days when stored at room temperature and protected from light.

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