Measuring Steroids in Hair Opens Up Possibilities to Identify Congenital Adrenal Hyperplasia in Developing Countries

May 2022 in “ Clinical endocrinology ”

Selma Waaijers, Agustini Utari, Rick H. A. van der Doelen, Sultana Mh Faradz, Renate Hensen-Lodewijk, André J. Olthaar, Paul J. Geutjes, Fred C.G.J. Sweep, Hedi L Claahsen–van der Grinten, Antonius E. van Herwaarden

congenital adrenal hyperplasia steroids glucocorticoid treatment liquid chromatography tandem mass spectrometry hair analysis CAH steroid measurement glucocorticoids LC-MS/MS

TLDR Hair steroid measurement is an effective method to diagnose and monitor CAH in developing countries.

The study involved 22 untreated Congenital Adrenal Hyperplasia (CAH) patients from Indonesia and 84 healthy volunteers from the Netherlands. It developed and validated a method to measure steroid concentrations in hair using liquid chromatography with tandem mass spectrometry (LC-MS/MS). The results showed that this method could be a viable way to diagnose and monitor CAH, especially in developing countries where traditional serum measurements are challenging. The method also showed potential for reducing costs and logistical issues associated with long-distance transport of frozen samples. The study confirmed the stability of steroids in hair for at least 3 weeks at 4°C and 30°C. After starting glucocorticoid treatment, the levels of steroids in hair decreased. This method could open up access to healthcare in developing countries and remote areas for people with CAH.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research Measuring Steroids in Hair Opens Up Possibilities to Identify Congenital Adrenal Hyperplasia in Developing Countries

3 citations, May 2022 in “Clinical endocrinology”

Hair steroid measurement is an effective method to diagnose and monitor CAH in developing countries.

research Steroid 17-Hydroxyprogesterone in Hair as a Potential Long-Term Biomarker of Androgen Control in Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency

10 citations, November 2019 in “Neuroendocrinology”

Measuring 17-hydroxyprogesterone in hair can help monitor androgen levels in people with congenital adrenal hyperplasia.

Related Community Posts Join

6 / 12 results

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 8 months ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community Transient and Permanent Effects of Finasteride Use

in Research/Science 154 upvotes 3 years ago

Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.

community Boys,Thank you all. almost 90days into treatment. dut/minox/ketoconazole shampoo

in Progress Pictures 75 upvotes 3 days ago

community Finasteride and Dutasteride results compilation thread

in Finasteride/Dutasteride 82 upvotes 3 weeks ago

Combining finasteride and dutasteride may enhance hair regrowth by targeting different enzymes, with positive results reported. Minoxidil, both oral and topical, is also used to improve effectiveness.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Stopping Dutasteride to have a baby

in Finasteride/Dutasteride 70 upvotes 1 week ago

A user plans to stop Dutasteride to conceive a child, seeking advice on hair maintenance. Suggestions include switching to Finasteride, but many emphasize prioritizing child safety.

Similar Research

6 / 1000+ results

research Congenital Adrenal Hyperplasia: Current Insights in Pathophysiology, Diagnostics, and Management

157 citations, May 2021 in “Endocrine Reviews”

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

research Congenital Adrenal Hyperplasia: A Comprehensive Review

88 citations, April 2017 in “Journal of Pediatric and Adolescent Gynecology”

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

research Nonclassic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency: Pathophysiology, Diagnosis, and Treatment

49 citations, January 2010 in “International Journal of Pediatric Endocrinology”

The document concludes that Nonclassic Congenital Adrenal Hyperplasia requires personalized treatment plans to manage symptoms and fertility, with glucocorticoids being a common therapy.

research Management of the Female With Non-Classical Congenital Adrenal Hyperplasia: A Patient-Oriented Approach

30 citations, June 2019 in “Frontiers in Endocrinology”

The document concludes that managing non-classical congenital adrenal hyperplasia in females requires personalized treatment, genetic counseling, and a team of specialists.

research Challenges in Treatment of Patients With Non-Classic Congenital Adrenal Hyperplasia

4 citations, December 2022 in “Frontiers in Endocrinology”

Treating non-classic congenital adrenal hyperplasia is complex because the benefits of hormone treatment must be weighed against potential health risks.

research Congenital Adrenal Hyperplasia

August 2022 in “IntechOpen eBooks”

Congenital Adrenal Hyperplasia is a rare inherited disease causing hormone imbalances, affecting growth, fertility, and heart health, diagnosed through blood tests and treated with medication and lifestyle changes.