Incorporation of Benzoyl Peroxide Nanocrystals Into Adapalene-Loaded Solid Lipid Microparticles: Part II – Solid-in-Oil Dispersion of Nanoparticulate Benzoyl Peroxide

The study explored a novel method to incorporate benzoyl peroxide nanocrystals into adapalene-loaded solid lipid microparticles to improve acne treatment by reducing side effects. The researchers used a lamellar liquid crystalline phase of a water/phospholipid system to stabilize a nanosuspension during freeze-drying, which preserved the nanodisperse character of benzoyl peroxide. This approach allowed for the creation of highly concentrated solid-in-oil systems that could be redispersed in both water and nonpolar fat phases with minimal size deviation. The method aimed to enhance follicular drug delivery and minimize skin irritation by targeting the release of active substances directly into hair follicles.