Incorporation of Benzoyl Peroxide Nanocrystals Into Adapalene-Loaded Solid Lipid Microparticles: Part II – Solid-in-Oil Dispersion of Nanoparticulate Benzoyl Peroxide

    November 2019 in “ International Journal of Pharmaceutics ”
    Christoph Brammann, Christel C. Müller-Goymann, Christoph Brammann, Christel C. Müller-Goymann
    TLDR The method improves acne treatment by enhancing drug delivery and reducing skin irritation.
    The study explored a novel method to incorporate benzoyl peroxide nanocrystals into adapalene-loaded solid lipid microparticles to improve acne treatment by reducing side effects. The researchers used a lamellar liquid crystalline phase of a water/phospholipid system to stabilize a nanosuspension during freeze-drying, which preserved the nanodisperse character of benzoyl peroxide. This approach allowed for the creation of highly concentrated solid-in-oil systems that could be redispersed in both water and nonpolar fat phases with minimal size deviation. The method aimed to enhance follicular drug delivery and minimize skin irritation by targeting the release of active substances directly into hair follicles.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 39 results

      community Minoxidil works only with Retinoic acid

      in Minoxidil  316 upvotes 4 months ago
      Minoxidil is more effective when combined with retinoic acid, such as tretinoin or tazarotene, enhancing hair growth. Some users experience significant regrowth, while others see minimal effects or side effects.

      community Hair Loss Inflammation Prevention Stack

      in Research/Science  49 upvotes 7 months ago
      The conversation discusses a hair loss and scalp care routine involving ciclopirox shampoo, benzoyl peroxide, clindamycin gel, clobetasol propionate, and calcipotriol to manage seborrheic dermatitis, folliculitis, and inflammation. It also touches on the role of diet and other treatments like oral minoxidil and pioglitazone for scalp health.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  410 upvotes 7 months ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

      community Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc...

      in Research/Science  133 upvotes 8 months ago
      Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

    Similar Research

    5 / 726 results